Showing Results for
- Academic Journals (22)
Search Results
- 22
Academic Journals
- 22
- Search Terms:
- 1From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedExposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found...
- 2From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedA hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to...
- 3From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedNature journals' updated editorial policies aim to improve transparency and reproducibility. As many of our readers know, early this year (Nat. Neurosci. 16, 1, 10.1038/nn0113-1, 2013) we developed a set of...
- 4From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedWhat makes certain individuals more vulnerable to drug abuse than others? A study finds that potentiation of glutamatergic inputs to nucleus accumbens indirect pathway neurons may protect against compulsive...
- 5From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedAmyotrophic lateral sclerois (ALS) is a debilitating neurodegenerative disease that is characterized by the death of motor neurons and a progressive loss of all motor function. The motor neuron degeneration seen in ALS...
- 6From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedDespite recent studies showing that inhibition of autophagy depletes the hematopoietic stem cell pool and increases intracellular reactive oxygen species (ROS), it remains unknown whether autophagy is essential in the...
- 7From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedIn the vibrissal system, touch information is conveyed by a receptorless whisker hair to follicle mechanoreceptors, which then provide input to the brain. We examined whether any processing, that is, meaningful...
- 8From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedRecent exome sequencing studies have implicated polymorphic Brg1-Associated Factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders....
- 9From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedOligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that...
- 10From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedAccumulated genetic evidence suggests that attenuation of the ratio between cerebral amyloid-[beta] A[beta]40 and A[beta]42 isoforms is central to familial Alzheimer's disease (FAD) pathogenesis. However, FAD mutations...
- 11From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedAstrocytes are thought to have important roles after brain injury, but their behavior has largely been inferred from postmortem analysis. To examine the mechanisms that recruit astrocytes to sites of injury, we used in...
- 12From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedAnimals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is,...
- 13From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedStressful experience initiates a neuroendocrine response culminating in the release of glucocorticoid hormones into the blood. Glucocorticoids feed back to the brain, causing adaptations that prevent excessive hormone...
- 14From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedWe found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression...
- 15From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedCognitive function declines as part of the normal aging process. A study finds that the dopamine-boosting drug L-DOPA changes value representation in the brain and improves reinforcement learning in older individuals....
- 16From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedA screen now identifies a protein that regulates degradation of mutant huntingtin, which causes Huntington's disease, and manipulations show that promoting clearance of the toxic protein itself may be sufficient to halt...
- 17From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedSenescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an...
- 18From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedA study in this issue suggests that neuronal DNA double-strand breaks can result from natural behaviors. The breaks occur in the circuits that are activated and are enhanced in a model of Alzheimer's disease. The...
- 19From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedHuntington's disease is caused by expanded CAG repeats in HTT, conferring toxic gain of function on mutant HTT (mHTT) protein. Reducing mHTT amounts is postulated as a strategy for therapeutic intervention. We conducted...
- 20From: Nature Neuroscience. (Vol. 16, Issue 5) Peer-ReviewedDecision making requires an actor to not only steer behavior toward specific goals but also determine the optimal vigor of performance. Current research and models have largely focused on the former problem of how...