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- 1From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedTo keep the malaria parasite in check, multiple antimalarial drugs are commonly blended into a single pill. Such artemisinin-based combination therapies are an effective way of thwarting the evolution of drug...
- 2From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedProposed changes to laws governing the use of nonhuman primates in research moved one step closer to adoption when the European Parliament voted in favor of the revisions last May. The changes would allow studies...
- 3From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedThe HIV drug raltegravir, which blocks viral integration into the genome, results in a transient increase in episomes, circularized HIV DNA. The findings suggest that persistent HIV replication occurs in people on...
- 4From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedVitamin D controls T cell antigen receptor signaling and activation of human T cells. von Essen, M.R. et al. Nat. Immunol. 4, 344-399. The molecular secret behind why it's good to have some fun in the sun. A key...
- 5From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedIn June 2005, radio engineer John Mountz was working 18-hour days, building a new studio in Houston, when his feet started to feel numb. By the next day, he had lost feeling below the knees, and a day later he had no...
- 6From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedUntil recently, buying most drugs in Lebanon was as easy as buying chewing gum. Even without showing a prescription, you could order a drug by phone and get it delivered directly to your door. This changed a few months...
- 7From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedHIV causes a chronic infection characterized by depletion of [CD4.sup.+] T lymphocytes and the development of opportunistic infections. Despite drugs that inhibit viral spread, HIV infection has been difficult to cure...
- 8From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedIn 2002, four years after first sparking public controversy over whether the measles, mumps and rubella vaccine causes autism, Andrew Wakefield reported a possible molecular mechanism for the connection. He claimed that...
- 9From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedBrain inflammation is a major factor in epilepsy, but the impact of specific inflammatory mediators on neuronal excitability is incompletely understood. Using models of acute and chronic seizures in C57BL/6 mice, we...
- 10From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedUnderstanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance,...
- 11From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedFeb 18 GE Healthcare and Henrik Thomsen reached a settlement in a libel suit brought by the company against the Danish clinician. Thomsen had stated at a conference that the company's magnetic resonance imaging contrast...
- 12From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedA man hands over a sack full of fake medicine. A pharmaceutical dealer grins at the sight of his latest delivery. A woman lays suffering on the floor of her hut, taking medicine she hopes will save her, only to die soon...
- 13From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedStem cell therapies in the Golden State might soon see the light of day-and the clinic. The California Institute for Regenerative Medicine (CIRM) announced last month that it will contribute up to $50 million toward...
- 14From: Nature Medicine. (Vol. 16, Issue 4) Peer-Reviewed"Counterfeit drugs kill!" reads the World Health Organization's (WHO's) anticounterfeiting slogan. Yet no one had ever calculated just how many deaths fake meds cause. So, last year, Andreas Seiter, the World Bank's...
- 15From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedIn type 2 diabetes and obesity, the homeostatic control of glucose and energy balance is impaired, leading to hyperglycemia and hyperphagia. Recent studies indicate that nutrient-sensing mechanisms in the body activate...
- 16From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedTwo reports in this issue identify a link between insulin action and the unfolded protein response--a pathway that helps the endoplasmic reticulum cope with cellular stress (pages 429-437 and 438-445). The results...
- 17From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedA new way to transiently knock down genes in mouse embryos may become a useful tool to understand neurodevelopmental disorders (Neuron 65, 480-489). A popular idea about schizophrenia and other psychiatric illnesses...
- 18From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedThalidomide, a drug reviled in the 1960s for its teratogenic effects, has been revived in recent years for cancer and leprosy therapy. A study now finds another use for this drug in vascular disease, providing further...
- 19From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedAnticounterfeiters and fraudulent drug makers are caught in a security arms race. No sooner do the good guys develop a new safeguard than the bad guys discover a workaround. Criminals have learned how to make...
- 20From: Nature Medicine. (Vol. 16, Issue 4) Peer-ReviewedTelomere elongation in induced pluripotent stem cells from dyskeratosis congenital patients. Agarwal, S. et al. Nature 464, 292-296. Researchers created induced pluripotent stem (iPS) cells from individuals with a...