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- 1From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedIt is well known in the field of acute myelogenous leukemia (AML) that many different translocations and genetic aberrancies are found with the various forms of the disease. Indeed, specific translocations are often...
- 2From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedRituximab, a chimeric CD20 monoclonal antibody (mAb), is widely used in the treatment of patients with low-grade non-Hodgkin's lymphoma. Possible anti-tumour mechanisms involve complement-mediated lysis and/or...
- 3From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedPrognostic factors of juvenile myelomonocytic leukemia (JMML) have not been clarified because of its very low incidence and inaccuracy in the diagnosis. The purpose of this study was to evaluate children with JMML given...
- 4From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe statin family of drugs target HMG-CoA reductase, the ratelimiting enzyme of the mevalonate pathway, and have been used successfully in the treatment of hypercholesterolemia for the past 15 years. Experimental...
- 5From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedAnti-leukemia activity of human macrophages involves the generation of nitric oxide (NO) derivatives. However, leukemic transformation may involve mechanisms that rescue cells from NO-mediated apoptosis. In the present...
- 6From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedAbout 30% of T cell acute lymphoblastic leukemias (T-ALL) carry TAL1 gene aberrations. In the majority of cases (approximately 25%), this concerns a submicroscopic deletion of -90 kb in chromosome region 1 p32, which...
- 7From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedPatients with chronic lymphocytic leukemia (CLL) are considered in nodular partial remission (nPR) when they are in remission but bone marrow biopsies show rare nodules. The significance of the level of residual disease...
- 8From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedConventional allogeneic hematopoietic stem cell transplantation (HSCT) strategies rely both on the high-dose combination chemotherapy or chemotherapy with high-dose total body irradiation conditioning and the allogeneic...
- 9From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedCellular stressors induce various outcomes including inhibition of cell proliferation and cell death. Sodium salicylate (SA), a plant stress hormone, can suppress the proliferation or cause apoptosis in certain mammalian...
- 10From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe standard paradigm of embryologic development and adult tissue reconstitution posits unidirectional, hierarchical lineages. The presumed mechanisms underlying these differentiative pathways are gene restrictions, such...
- 11From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedMantle cell lymphoma (MCL) is a distinct clinico-pathological entity with a poor prognosis. We have conducted a prospective study in patients with MCL to evaluate a therapeutic strategy in which CHOP polychemotherapy was...
- 12From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe objective of this study was to assess toxicity and feasibility of achieving engraftment of allogeneic blood progenitor cells following nonmyeloablative conditioning according to the FCIE protocol (fludarabine 25...
- 13From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedRecent studies have shown that arsenic trioxide ([AS.sub.2][O.sub.3]) can induce complete remission in patients with acute promyelocytic leukemia (APL). We tested the efficacy and safety of [AS.sub.2][O.sub.3] for the...
- 14From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe development of immunotherapeutic strategies for the treatment of leukemia and other cancers has long been of interest. Natural killer (NK) cells represent one component of the innate immune system and have the...
- 15From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe objective of this study was to identify biologic parameters that were associated with either exceptionally good or poor outcome in childhood acute myeloid leukemia (AML). Among the children with AML who entered...
- 16From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedHematopoietic stem cells give rise to immature progenitors of each of the hematopoietic lineages, including megakaryocytes for which thrombopoietin (TPO) plays an important role in their development. Less is known about...
- 17From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedRetinoids are important mediators of cellular growth and differentiation. Retinoids modulate the growth of both normal and malignant cells through their binding to retinoid nuclear receptors and their subsequent...
- 18From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedActivation of the MEK/ERK/MAP kinase signaling pathway promotes the proliferation and survival of hematopoietic cells. The kinases MEK-1, MEK-2, ERK-1/MAPK and ERK-2/MAPK are activated by phosphorylation at specific...
- 19From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe MCL1 gene (myeloid cell leukemia-1) was discovered serendipitously about a decade ago and proved to be a member of the emerging BCL2 gene family. Ongoing studies of this gene provide an interesting perspective on the...
- 20From: Leukemia. (Vol. 16, Issue 4) Peer-ReviewedThe Raf/MEK/ERK (MAPK) signal transduction cascade is a vital mediator of a number of cellular fates including growth, proliferation and survival, among others. The focus of this review centers on the MAPK signal...