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- 1From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Gary S Firestein1 Observer la nature, et suivez la route qu'elle vous trace. JJ Rousseau, quoted in [1]. Over 150 years ago, Garrod coined the term 'rheumatoid arthritis' (RA) to distinguish it from...
- 2From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Philip C Robinson1 and Matthew A Brown1 Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton and pelvis. Regardless of whether it progresses onto ankylosing spondylitis (AS),...
- 3From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for compounds to improve the effect of classic steroids. We sought to unravel how a...
- 4From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction Our objective was to utilise network analysis to identify protein clusters of greatest potential functional relevance in the pathogenesis of oligoarticular and rheumatoid factor negative (RF-ve)...
- 5From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL...
- 6From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Chanchal Sur Chowdhury1 , Stavros Giaglis1,2 , Ulrich A Walker3 , Andreas Buser4 , Sinuhe Hahn1 and Paul Hasler2 A novel feature of the biology of polymorphonuclear granulocytes (PMNs) is their ability to...
- 7From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction Relatively little is known about cellular subpopulations in the mature nucleus pulposus (NP). Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional...
- 8From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-Reviewed
Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis
Author(s): Kwi Young Kang1 , In Je Kim2 , Seung Min Jung3 , Seung-Ki Kwok3 , Ji Hyeon Ju3 , Kyung-Su Park3 , Yeon Sik Hong1 and Sung-Hwan Park3 Ankylosing spondylitis (AS) is a chronic inflammatory disease that... - 9From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Jasvinder A Singh1,2,3 Gout is the most common type of inflammatory arthritis in adults. Gout affects 8.3 million Americans [1] and 5% of the US veterans [2]. It leads to frequent emergency room visits [3]...
- 10From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Mandy J Peffers1 , Berta Cillero-Pastor2 , Gert B Eijkel2 , Peter D Clegg1 and Ron MA Heeren2 Osteoarthritis (OA) is an age related joint disease characterized by alterations in the chondrocytes and loss...
- 11From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Bridgette D Furman1 , Daniel S Mangiapani1 , Evan Zeitler1 , Karsyn N Bailey1 , Phillip H Horne1 , Janet L Huebner2 , Virginia B Kraus2 , Farshid Guilak1 and Steven A Olson1 Osteoarthritis (OA) is a...
- 12From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Esmeralda N Blaney Davidson1 , Fons AJ van de Loo1 , Wim B van den Berg1 and Peter M van der Kraan1 Building an inducible cartilage-specific transgenic mouse When researching cartilage, one will soon...
- 13From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Aryeh M Abeles1 In the previous issue of Arthritis Research and Therapy , Hershfield and colleagues published a study putting forth a number of novel and potentially important findings regarding...
- 14From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedPerturbed epigenetic landscape and deregulated microRNA networks are central to the permanent activation and aggressiveness of synovial fibroblasts in rheumatoid arthritis. Current anti-cytokine therapies, although...
- 15From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction We aimed to evaluate the effect of menopause on skin thickening, as measured by the modified Rodnan skin score (mRSS), in women with systemic sclerosis (SSc). Methods We identified women with...
- 16From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction The elevated risk of ischaemic heart disease in patients with rheumatoid arthritis (RA) has been linked to inflammation and disease severity. Treatment with tumour necrosis factor inhibitors (TNFis) is...
- 17From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Pierre Miossec1 During the last 20 years, obvious progress has been made in the care of patients with rheumatoid arthritis (RA). This results from the combination of better diagnosis, earlier use of...
- 18From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedIntroduction C-X-C motif chemokine 10 (CXCL10) is a chemokine that plays a critical role in the infiltration of T cells in autoimmune diseases and is reported to be expressed in muscle tissue of polymyositis. To...
- 19From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Tamarah D de Jong1 , Saskia Vosslamber1 and Cornelis L Verweij1,2 In rheumatoid arthritis (RA), therapies with biologics targeting TNF[alpha], IL-6 receptor, T-cell co-stimulation, and B cells are...
- 20From: Arthritis Research & Therapy. (Vol. 16, Issue 3) Peer-ReviewedAuthor(s): Ling Zhao1 , Ke Cheng1,2 , Lizhen Wang1 , Fan Wu1 , Haiping Deng1 , Ming Tan3,4 , Lixing Lao1,4,5 and Xueyong Shen1,2 Knee osteoarthritis (KOA), common among the elderly, significantly affects patient...