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- 1From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedIt is known that the level of interleukin-6 (IL-6) is higher in patients with active Behcet's disease (BD) than in those with inactive disease. Herpes simplex virus (HSV) type 1 inoculation of the earlobes of ICR mice...
- 2From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedEngineered foamy virus (FV) vectors have been lauded for their superior safety profiles and stable integration patterns compared to their gammaretroviral counterparts. The drawback has been the belief that FV...
- 3From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedIschemia/reperfusion (I/R) injury is an unavoidable barrier that significantly affects outcome of solid organ transplantation. Here, we establish a protein transduction system to extend graft preservation time and to...
- 4From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedThe efficacy of current anti-cancer gene therapies is limited by the inability of gene vectors to penetrate the poorly vascularized, hypoxic regions of tumors, leaving these sites untreated. We describe a new approach...
- 5From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedIn vivo bioluminescence imaging of reporter enzymes has proven to be a uniquely powerful tool that allows the study of the biology of viral and nonviral gene transfer agents. Cost-effective, noninvasive, longitudinal...
- 6From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedBillions of neurons are interconnected in the central nervous system (CNS). Identification of specific neuronal circuit is indispensable for understanding the relationship between structure and function in the CNS. The...
- 7From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedA replication-incompetent adenoviral vector encoding the heavy chain C-fragment ([H.sub.C]50) of botulinum neurotoxin type C (BoNT/C) was evaluated as a mucosal vaccine against botulism in a mouse model. Single...
- 8From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedPeriodontal disease is a chronic inflammatory condition induced by tooth-associated microbial biofilms that induce a host immune response. Therapeutic control of progressive tissue destruction in high-risk patients is a...
- 9From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedReplicon plasmids encoding an alphavirus RNA replicase constitute an alternative to conventional DNA plasmids with promise for DNA vaccination in humans. Replicase activity amplifies the levels of transgene mRNA through...
- 10From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedAlthough gene transfer by retroviral vectors has shown its potential for the correction of three different inherited disorders of the haematopoietic system, (1-4) hopes of rapidly available therapeutic solutions have...
- 11From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedA number of preclinical studies have shown the adeno-associated virus (AAV) to be an efficient vehicle for gene therapy. Clinical studies successfully demonstrated its potential for in vivo gene transfer. The complexity...
- 12From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedWe previously reported the development of a prototype 'oncolytic Sendai virus (SeV) vector' formed by introducing two major genomic modifications to the original SeV, namely deletion of the matrix (M) gene to avoid...
- 13From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedOur pre-clinical studies demonstrated that intratumoral vaccination with a recombinant oncolytic type 2 adenovirus overexpressing the heat shock protein (HSP)70 protein, designated as H103, can inhibit primary and...
- 14From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedThe effectiveness of genetic engineering with lentivectors to protect transplanted cells from allogeneic rejection was examined using, as a model, type 1 diabetes treatment with β-cell transplantation, whose widespread...
- 15From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedNeural progenitor cells are potential vehicles for delivery of therapeutic agents into the brain. Differentiation-dependent promoters may be useful to target the therapeutic transgene expression to specific neural cell...
- 16From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedInterleukin-10 (IL-10) ameliorates various T-helper type 1 cell-mediated chronic inflammatory diseases. Although the therapeutic benefits of IL-10 include antiatherosclerotic effects, pathophysiological effects of IL-10...
- 17From: Gene Therapy. (Vol. 16, Issue 3) Peer-ReviewedStem cells from a patient with a genetic disease could be used for cell therapy if it were possible to insert a functional copy of the defective gene. In this study, we investigate the transfection and subsequent...