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- 1From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedInfluenza B is a substantial component of the annual mix of seasonal flu viruses. One of the essential proteins in this virus is BM2, a small membrane protein with a single transmembrane helix that, as a tetramer, forms...
- 2From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedFrom flocking common grackles, birds that in their hundreds shake the branches of autumnal oak trees and then eat the dislodged acorns, to dolphins that act together to trap hapless fish and then feast, the advantages...
- 3From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe second messenger signaling molecule bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates many processes in bacteria, including motility, pathogenesis and biofilm formation. c-di-GMP-binding...
- 4From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedMitotic chromosomal assembly in vertebrates is regulated by condensin I and condensin II, which work cooperatively but have different chromosomal localization profiles and make distinct mechanistic contributions to this...
- 5From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe ring-shaped cohesin complex links sister chromatids and functions as a structural barrier for the transcriptional machinery at insulators and boundary elements. As a result, cohesin frequently accumulates in certain...
- 6From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedIn the version of this article initially published, Eric A. Gaucher's middle initial was omitted. The error has been corrected in the HTML and PDF versions of the article. Raul Perez-Jimenez, Jingyuan Li, Pallav...
- 7From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedDNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an...
- 8From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe spliceosome is a ribonucleoprotein machine that removes introns from pre-mRNA in a two-step reaction. To investigate the catalytic steps of splicing, we established an in vitro splicing complementation system....
- 9From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedSepsis is an acute systemic inflammatory response triggered by infection; severe cases can result in multiple organ dysfunction and failure, septic shock and death. The use of recombinant activated protein C (APC) to...
- 10From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedStrong voltage sensitivity of inward-rectifier [K.sup.+] (Kir) channels has been hypothesized to arise primarily from an intracellular blocker displacing up to five [K.sup.+] ions from the wide, intracellular part of...
- 11From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedInfluenza B virus contains an integral membrane protein, BM2, that oligomerizes in the viral membrane to form a pH-activated proton channel. Here we report the solution structures of both the membrane-embedded channel...
- 12From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedOn 3 November our community lost a young, extremely talented scientist under tragic circumstances when Warren DeLano died suddenly. To the readers of Nature Structural & Molecular Biology and to the larger biochemical...
- 13From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedPotassium channels allow [K.sup.+] ions to diffuse through their pores while preventing smaller [Na.sup.+] ions from permeating. Discrimination between these similar, abundant ions enables these proteins to control...
- 14From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe human cancer predisposition syndrome Fanconi anemia (FA) results from mutations in a pathway involved in repair of DNA interstrand cross-links (ICLs). Thirteen FA complementation groups (corresponding to 13 FANC...
- 15From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedArgonaute (AGO) proteins bind to small RNAs and mediate small RNA-induced silencing in eukaryotes. Using a minimal in vitro system, we show that bacterially expressed human AGO1 and AGO2 but not AGO3 and AGO4 possess...
- 16From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedTelomere protection allows cells to distinguish their natural chromatid ends from broken DNA and therefore permits the maintenance of genomes in the form of linear chromosomes. Many parameters contribute to protection...
- 17From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedIon binding to secondary active transporters triggers a cascade of conformational rearrangements resulting in substrate translocation across cellular membranes. Despite the fundamental role of this step, direct...
- 18From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe protein kinase TAK1 is activated by binding to Lys63 (K63)-linked ubiquitin chains through its subunit TAB2. Here we analyze crystal structures of the TAB2 NZF domain bound to Lys63-linked di- and triubiquitin,...
- 19From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedThe cyclic diguanylate (bis-(3'-5')-cyclic dimeric guanosine monophosphate, c-di-GMP) riboswitch is the first known example of a gene-regulatory RNA that binds a second messenger. c-di-GMP is widely used by bacteria to...
- 20From: Nature Structural and Molecular Biology. (Vol. 16, Issue 12) Peer-ReviewedWithin a cellular environment, biological macromolecules constantly encounter the immense task of pinpointing the correct binding partner among thousands of different potential candidates. In addition, this interaction...