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- 1From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedVectors based on the adeno-associated virus (AAV) are attractive and versatile vehicles for in vivo gene transfer. The virus capsid is the primary interface with the cell that defines many pharmacological, immunological...
- 2From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedOncolytic herpes simplex viruses type 1 (oHSVs) such as G47Δ and G207 are genetically engineered for selective replication competence in cancer cells. Several factors can influence the overall effectiveness of oHSV...
- 3From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedX-linked chronic granulomatous disease (X-CGD) is an inherited immunodeficiency with absent phagocyte NADPH-oxidase activity caused by defects in the gene-encoding [gp91.sup.phox]. Here, we evaluated strategies for less...
- 4From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedHemagglutinating virus of Japan envelope (HVJ-E) vector with inactivated replication-defective Sendai virus was originally developed as a versatile drug delivery system. Recently, we have shown the direct tumor-killing...
- 5From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedThe E2F-1 promoter has been used to confer tumor-selective E1A expression in oncolytic adenoviruses. Tumor specificity is mainly conferred by a unique structure of E2F-responsive sites organized in palindromes. Binding...
- 6From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedThe lack of efficient in vivo gene delivery is a well-known shortcoming of nonviral delivery vectors, in particular of chemical vectors. We developed a series of novel nonviral carriers for plasmid-based in vivo gene...
- 7From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedIn this study, we describe a novel self-contained, nonviral vector system for the rapid development of tetracycline (Tet)-inducible transgene expression systems in mammalian cell lines. To avoid multiple rounds of clonal...
- 8From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedAdenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads to weak tumor transduction....
- 9From: Gene Therapy. (Vol. 16, Issue 12) Peer-ReviewedCancer gene therapy by adenovirus vectors (Advs) for metastatic cancer is limited because systemic administration of Adv produces low therapeutic effect and severe side effects. In this study, we generated a dual...