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- 1From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedVaccine development against flaviviruses, a group of positive-strand RNA viruses that include West Nile virus (WNV) and dengue virus, has been limited. Traditional vaccination methods using live-attenuated virus risk the...
- 2From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedEri1 is a 3'-to-5' exoribonuclease conserved from fission yeast to humans. Here we show that Eri1 associates with ribosomes and ribosomal RNA (rRNA). Ribosomes from Eri1-deficient mice contain 5.8S rRNA that is...
- 3From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedChromosomal breaks destabilize the genome and can cause developmental defects and diseases such as cancer. New work suggests that, shortly after DNA damage, dissociation of the histone binding protein HPlβ from chromatin...
- 4From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedFlagella are long filamentous appendages used by bacteria to move around. Flagellar filaments are polymers of the protein flagellin. The sequence conservation of flagellin from different bacteria might be due to...
- 5From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedSeveral protein kinases, including SRPK1 and SRPK2, have been implicated in spliceosome assembly and catalytic activation. However, little is known about their targets. Here we show that SRPK1 is predominantly associated...
- 6From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedNat. Struct. Mol. Biol. 15,452-461 (2008); published online 4 May; corrected after print 15 May 2008 In the version of this article initially published, the concentration units reported in Figure 76,c should be nM, not...
- 7From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedGenetic mutations can alter the primary sequence of a protein, and are linked to a broad range of diseases. Such mutations can also produce a premature termination codon (PTC); translation of an mRNA containing one of...
- 8From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedThe spliceosome uses numerous strategies to regulate its function in mRNA maturation. Ubiquitin regulates many cellular processes, but its potential roles during splicing are unknown. We have developed a new strategy...
- 9From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedThe report by the US National Academy of Sciences, the National Academy of Engineering and the Institute of Medicine, entitled XisingAbove the Gathering Storm: Energizing and EmploYing America for a Brighter Economic...
- 10From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedWe identify the helicase-SANT-associated (HSA) domain as the primary binding platform for nuclear actin-related proteins (ARPs) and actin. Individual HSA domains from chromatin remodelers IRK, yeast SWI-SNF, human...
- 11From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedA heterotrimeric complex of minor pseudopilins from the type II secretion system has been identified and its crystal structure solved. Although each subunit shares the same overall α-fold as other characterized...
- 12From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedThe eukaryotic DNA replication machinery must traverse every nucleosome in the genome during S phase. As nucleosomes are generally inhibitory to DNA-dependent processes, chromatin structure must undergo extensive...
- 13From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedThe kinetics of Ras activation by Son of sevenless (SOS) changes profoundly when Ras is tethered to membranes, instead of being in solution. SOS has two binding sites for Ras, one of which is an allosteric site that is...
- 14From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedSemaphorins (SMPs) are Plexin (PLX) receptor ligands involved in developmental processes. Translational regulation has been suggested to mediate SMP signaling, but the mechanism and targets of such regulation are...
- 15From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedThe splicing pathway is dominated by ATP-dependent RNA rearrangements promoted by DEAD-box helicases. Post-translational modifications have now been implicated in the regulation of two DEAD-box proteins that are required...
- 16From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedIn contrast to the diversity of most ribosomal RNA modification patterns and systems, the KsgA methyltransferase family seems to be nearly universally conserved along with the modifications it catalyzes. Our data reveal...
- 17From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedRibosomes synthesizing inner membrane proteins in Escherichia coli are targeted to the translocon in the plasma membrane by the signal recognition particle (SRP) and the SRP receptor, FtsY. Here we show using a purified...
- 18From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedGram-negative bacteria translocate various proteins including virulence factors across their outer membrane via type 2 secretion systems (T2SSs). T2SSs are thought to contain a pseudopilus, a subcomplex formed by one...
- 19From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedInfluenza virus mRNAs are synthesized by the trimeric viral polymerase using short capped primers obtained by a 'cap-snatching' mechanism. The polymerase PB2 subunit binds the 5' cap of host pre-mRNAs, which are cleaved...
- 20From: Nature Structural and Molecular Biology. (Vol. 15, Issue 5) Peer-ReviewedSince the discovery that actin and actin-related proteins (ARPs) reside in the nucleus as integral subunits of chromatin-modifying and chromatin-remodeling complexes, efforts to uncover their roles in chromatin...