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- 1From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedThe variable efficacy of Bacille Calmette Guerin (BCG) vaccination against tuberculosis has prompted efforts to improve the vaccine. In this study, we used autophagy to enhance vaccine efficacy against tuberculosis in a...
- 2From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedOxidative stress might be at the root of some traits characteristic of fragile X syndrome, the most frequent form of inborn mental retardation (PLoS Biol. 7, e1000016). Mutations in the RNA-binding molecule Fragile X...
- 3From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedProponents of medical marijuana are reeling after the US Drug Enforcement Agency (DEA) rejected a recommended ruling issued by the agency in 2007 and then refused to grant a license to grow marijuana for research to...
- 4From: Nature Medicine. (Vol. 15, Issue 3) Peer-Reviewed
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral... - 5From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedScott G Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C Siess, Derek D Drummond, Alfred W Legasse, Michael K Axthelm, Kelli Oswald, Charles M Trubey, Michael Piatak Jr, Jeffrey D Lifson, Jay A...
- 6From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedDespite considerable advances in our understanding of neurodegenerative disease pathogenesis, options for meaningful therapeutic intervention for such disorders remain limited. An appreciation of the mechanistic basis...
- 7From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedA recent case of mushroom poisoning has highlighted the difficulties of investigating treatments for a rare illness. In late December, a woman and her two grandsons in California ate soup made from deadly Amanita...
- 8From: Nature Medicine. (Vol. 15, Issue 3) Peer-Reviewed
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
Interleukin-10 is known to dampen immune responses and contribute to the persistence of chronic viruses and parasites. Thomas Braciale and his colleagues show in mice that the anti-inflammatory cytokine is produced,... - 9From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedTateishi, K., Okada, Y., Kallin, E.M. & Zhang, Y. Nature published online, doi:10.1038/ nature07777 (4 February) A demethylase regulates metabolic gene expression and helps maintain normal weight control in mice. The...
- 10From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedFindings in knockout mice indicate that hypoxia-sensitive pathways modulate the glucose-sensing machinery of pancreatic beta cells. Conditions that mimic hypoxia severely impair glucose-stimulated insulin release....
- 11From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedIssue:Vaccines that induce T cell responses to simian immunodeficiency virus are able to reduce virus load in infected macaques. Such vaccines typically induce central memory T cells that must expand before gaining full...
- 12From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedCalcium channels control breast cancer metastasis by regulating cell migration, researchers have found. The results suggest that some calcium channel inhibitors could be used as anticancer therapies. Previous work...
- 13From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedMatthew Husa, Ru Liu-Bryan & Robert Terkeltaub Nat. Med. 15, 641-644 (2010), published online 4 June 2010; corrected online 7 July 2010 In the version of this article initially published online, a reference was...
- 14From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedNat. Med. 15, 293-299 (2009) Scott G Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C Siess, Derek D Drummond, Alfred W Legasse, Michael K Axthelm, Kelli Oswald, Charles M Trubey, Michael Piatak...
- 15From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedJan 18 A genome-wide comparison of DNA from nearly 200 of twins revealed stronger similarities in methylation patterns between identical twins compared with fraternal twins, providing evidence for molecular...
- 16From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedAn experimental simian immunodeficiency virus vaccine boosts production of memory T cells at the site where the virus first contacts the body--in the mucosa (293-299). The approach has the potential to result in more...
- 17From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedAntibodies recognizing a post-translational protein modification common in several inflammatory diseases can induce arthritis, according to a new report in mice (J. Exp. Med. 206, 449-462). This modification, called...
- 18From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedThe world's first clinical trial using embryonic stem cells has received approval in the US, leaving experts in other countries to ponder whether an improved climate for such research within the US will force them to...
- 19From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedFollowing similar initiatives from drug companies such as Eli Lilly, Merck and GlaxoSmithKline last year, the pharmaceutical giant Pfizer announced on 9 February that it will publicly disclose its compensation of US...
- 20From: Nature Medicine. (Vol. 15, Issue 3) Peer-ReviewedMany tumors respond to radiation treatment, but often the cancer comes back. New findings suggest that cells thought to seed tumor growth, cancer stem cells, might resist such treatment because they deflect damage from...