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- 1From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedActive cancer immunotherapy relies on functional tumor-specific effector T lymphocytes for tumor elimination. Dendritic cells (DCs), as most potent antigen-presenting cells, have been popularly employed in clinical and...
- 2From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedAnaplastic thyroid carcinoma is the most aggressive type of thyroid malignancies. Previously, we demonstrated that tumorigenicity of anaplastic thyroid carcinoma cell line ARO was significantly reduced following...
- 3From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedWe have previously described oncolytic adenovirus (Ad) vectors KD3 and KD3-interferon (IFN) that were rendered cancer-specific by mutations in the E1A region of Ad; these mutations abolish binding of E1A proteins to...
- 4From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedIn this study, we assessed the ability of a highly tumor-selective oncolytic vaccinia virus armed with a yeast cytosine deaminase gene to infect and lyse human and murine ovarian tumors both in vitro and in vivo. The...
- 5From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedIrinotecan (CPT-11) is a key drug for the treatment of various cancers. CPT-11 can be considered to be a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme ca rboxylesterase. However, CPT-11...
- 6From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedThe three-component nanoparticle of this investigation consisted of an anti-type I regulatory subunit α of the cyclic AMP-dependent protein kinase A (RIα) antisense phosphorodiamidate morpholino (MORF) oligomer, a tat...
- 7From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedProstate cancer is the most common malignant tumor in men and is normally associated with increased serum levels of prostate-specific antigen (PSA). Therefore, PSA is one potential target for a prostate cancer vaccine....
- 8From: Cancer Gene Therapy. (Vol. 15, Issue 2) Peer-ReviewedA recently developed, adaptive constant-current electroporation technique was used to immunize mice with an intramuscular injection of plasmid coding for the extracellular and transmembrane domains of the product of the...