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- 1From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedA study now finds early memory impairment in a mouse model of amyloid [beta]43 (A[beta]43)-overproducing familial Alzheimer's disease and suggests that this overlooked amyloidogenic A[beta] species contributes to...
- 2From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedWhen learned in quick succession, declarative and motor skill tasks interfere with one another and subsequent recall is impaired. Depending on the order of the tasks, we were able to prevent memory interference in...
- 3From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedControversy surrounds the suggestion that recursion is a uniquely human computational ability that enables language. A study now finds this ability in a songbird and takes steps toward a model system for syntactic...
- 4From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedDNA methylation-dependent epigenetic mechanisms underlie the development and function of the mammalian brain. MeCP2 is highly expressed in neurons and functions as a molecular linker between DNA methylation, chromatin...
- 5From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedThe scenario is familiar to many of us at some point or another in our careers; after spending years working on a project and building what we think is a complete story, the long-awaited reviews finally arrive with a...
- 6From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedWhether the computational systems in language perception involve specific abilities in humans is debated. The vocalizations of songbirds share many features with human speech, but whether songbirds possess a similar...
- 7From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedThe owl captures prey using sound localization. In the classical model, the owl infers sound direction from the position of greatest activity in a brain map of auditory space. However, this model fails to describe the...
- 8From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedZinc is abundant in the central nervous system and regulates pain, but the underlying mechanisms are unknown. In vitro studies have shown that extracellular zinc modulates a plethora of signaling membrane proteins,...
- 9From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedNeuronal responses during sensory processing are influenced by both the organization of intracortical connections and the statistical features of sensory stimuli. How these intrinsic and extrinsic factors govern the...
- 10From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedThe protein kinase calcium/calmodulin-dependent kinase II (CaMKII) predominantly consists of the a and [beta] isoforms in the brain. Although CaMKII[alpha] functions have been elucidated, the isoform-specific catalytic...
- 11From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedTo best interpret new sensory information, populations of sensory neurons must represent the lessons of past experience. How do they do this? The same solution to this problem is now reported in two very different...
- 12From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedMaking associations between sensory stimuli is a critical aspect of behavior. We previously found that neurons in the lateral intraparietal area (LIP) of Macaca mulatta reflect learned associations between directions of...
- 13From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedMost regions of the CNS contain many subtypes of inhibitory interneurons with specialized roles in circuit function. In the mammalian retina, the ~30 subtypes of inhibitory interneurons called amacrine cells (ACs) are...
- 14From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedLaminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals by sensory endings in the skin requires...
- 15From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedAnimals cope with environmental changes by altering behavioral strategy. Environmental information is generally received by sensory neurons in the neural circuit that generates behavior. However, although environmental...
- 16From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedMultiphoton imaging (MPI) is widely used for recording activity simultaneously from many neurons in superficial cortical layers in vivo. We combined regenerative amplification multiphoton microscopy (RAMM) with...
- 17From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedDopamine (DA) [D.sub.2] receptors expressed in DA neurons ([D.sub.2] autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As [D.sub.2] receptors are mostly...
- 18From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedRetinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained...
- 19From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedBoth natural rewards and addictive drugs increase extracellular dopamine (DA) in the striatum. Although studies have found that DA receptors are involved in addiction, the results are conflicting. Susceptibility to drug...
- 20From: Nature Neuroscience. (Vol. 14, Issue 8) Peer-ReviewedIn terrestrial vertebrates, sniffing controls odorant access to receptors, and therefore sets the timescale of olfactory stimuli. We found that odorants evoked precisely sniff-locked activity in mitral/tufted cells in...