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- Search Terms:ISSN: 14655411AndISSN: 1465542XAndVolume Number: 14AndIssue Number: 5AndStart Page: 323AndDate: 2012 Revise Search
- 1From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Tumor cell migration and invasion are critical initiation steps in the process of breast cancer metastasis, the primary cause of breast cancer morbidity and death. Here we investigated the role of...
- 2From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6...
- 3From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The gene quiescin/sulfhydryl oxidase 1, QSOX1, encodes an enzyme directed to the secretory pathway and excreted into the extracellular space. QSOX1 participates in the folding and stability of proteins...
- 4From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by...
- 5From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of...
- 6From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The presence of circulating tumor cells (CTC) is an independent prognostic factor for progression-free survival and breast cancer-related death (BRD) for patients with metastatic breast cancer beginning...
- 7From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Metastasis of breast cancer is the main cause of death in patients. Previous genome-wide studies have identified gene-expression patterns correlated with cancer patient outcome. However, these were...
- 8From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The TWIST homolog 1 (TWIST1) is a transcription factor that induces epithelial to mesenchymal transition (EMT), a key process in metastasis. The purpose of this study was to investigate whether TWIST1...
- 9From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Changes in sex hormones with weight loss might have implications for breast cancer prevention but have not been examined extensively, particularly in African-American (AA) women. Methods We...
- 10From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA...
- 11From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The organisation of the mammary epithelial hierarchy is poorly understood. Our hypothesis is that the luminal cell compartment is more complex than initially described, and that an understanding of the...
- 12From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The Ets-1 transcription factor is a candidate breast cancer oncogene that regulates the expression of genes involved in tumor progression and metastasis. Ets-1 signaling has also been linked to the...
- 13From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction NOTCH activation has been recently implicated in human breast cancers, associated with a poor prognosis, and tumor-initiating cells are hypothesized to mediate resistance to treatment and disease...
- 14From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the...
- 15From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by...
- 16From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction In gene expression experiments, hormone receptor (HR)-positive/human epidermal growth factor-2 (HER2)-positive tumors generally cluster within the luminal B subset; whereas HR-negative/HER2-positive...
- 17From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall...
- 18From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Mena, an Ena/VASP protein family member, is a key actin regulatory protein. Mena is up-regulated in breast cancers and promotes invasion and motility of tumor cells. Mena has multiple splice variants,...
- 19From: Breast Cancer Research. (Vol. 14, Issue 5) Peer-ReviewedIntroduction Intrinsic plasticity of breast carcinoma cells allows them to undergo a transient and reversible conversion into mesenchymal cells to disseminate into distant organs, where they can re-differentiate to...