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- Search Terms:ISSN: 1471003XAndISSN: 14710048AndVolume Number: 14AndIssue Number: 4AndStart Page: 225AndDate: 2013 Revise Search
- 1From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedSeveral recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this neurodegenerative disease and raising the...
- 2From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedLittle is known about the molecular mechanisms that mediate the consolidation of short-term memory into long-term memory. Costa-Mattioli and colleagues now show a crucial role for mammalian target of rapamycin complex 2...
- 3From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedMicroglia are not only crucial in the response to neuronal damage--their role in the normal brain, including in brain development, is becoming increasingly evident. McCarthy and colleagues now add to the functional...
- 4From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedInverse comorbidity is a lower-than-expected probability of disease occuring in individuals who have been diagnosed with other medical conditions. Emerging evidence points to inverse cancer comorbidity in people with...
- 5From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedSignalling through NMDA receptors (NMDARs) can trigger cell death or survival depending on whether activation of such receptors occurs at extrasynaptic or synaptic sites, respectively. It is unclear how these opposing...
- 6From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedThe role of defects in adult-born neurons in schizophrenia and in other psychiatric conditions that are often classed as neurodevelopmental disorders remains unclear. However, a study in mice now shows that the...
- 7From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedAlthough low concentrations of salt in food are appetitive, salt becomes aversive with increasing concentration, thus helping to avoid excessive consumption that would disrupt electrolyte homeostasis. The mechanism...
- 8From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedThe aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the principal member of this protein family in the CNS, where it is expressed in astrocytes and is involved in water movement, cell...
- 9From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedLittle is known about why certain types of neurons are more susceptible to microbial infection than others. Diamond and colleagues examined the differential permissivity of neurons from distinct brain regions to...
- 10From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedDespite intense research into the pathophysiology and treatment of depression, the onset of symptom relief with current antidepressants is slow, and many patients fail to achieve full remission. Now, Nasca et al. show...
- 11From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedThe inhibitory neurotransmitter GABA activates both ionotropic type A GABA receptors ([GABA.sub.A]Rs) and metabotropic GABAB receptors ([GABA.sub.B]Rs). Two independent studies in rat brain slices now show that...
- 12From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedMyosins are a large family of actin-based cytoskeletal motors that use energy derived from ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have specific pre- and postsynaptic roles that...
- 13From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedHexanucleotide (GGGGCC) repeat expansions in C9ORF72 (chromosome 9 open reading frame 72) are the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). These disorders are...
- 14From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedCommon genetic variants in humans have been associated with an increased risk of Parkinson's disease (PD), but it has been difficult to define the mechanisms by which these variants predispose individuals to disease....
- 15From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedCorticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons,...
- 16From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedMajor depressive disorder (MDD) is notoriously difficult to treat in the long term. In mice subjected to chronic social defeat stress (a preclinical model of depression-like behaviours), the authors found both reduced...
- 17From: Nature Reviews Neuroscience. (Vol. 14, Issue 4) Peer-ReviewedStudies in animals and humans have shown that memories, once reactivated, undergo reconsolidation that depends, like the initial consolidation of a memory, on protein synthesis. In some circumstances, pharmacological...