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- 1From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedMaintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner (1,2). Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback...
- 2From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedLarge pleiomorphic carriers leave the Golgi complex for the plasma membrane by en bloc extrusion of specialized tubular domains, which then undergo fission. Several components of the underlying molecular machinery have...
- 3From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedThe California Institute of Regenerative Medicine (CIRM) was established in 2004 by Proposition 71 (http://www.cirm.ca.gov/pdf/ prop71.pdf), which mandated support of stem cell research through state funding. Funding...
- 4From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedThe cilium is a microtubule-based organelle that contains a unique complement of proteins for cell motility and signalling functions. Entry into the ciliary compartment is proposed to be regulated at the base of the...
- 5From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedCorrect chromosome segregation depends on mechanisms sensing the attachment of chromosomes to the spindle. Lack of tension between sister kinetochores produces a conformational change in the kinetochore, but a detailed...
- 6From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedFbxw7[alpha] is a member of the F-box family of proteins, which function as the substrate-targeting subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes. Using differential purifications and mass...
- 7From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedThe epithelial-mesenchymal transition (EMT) is a key morphogenetic program during normal embryonic development, characterized by loss of cell adhesion and increased cell motility (1). The EMT is often co-opted by cancer...
- 8From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedSeamless tubes form intracellularly without cell-cell or autocellular junctions. Such tubes have been described across phyla, but remain mysterious despite their simple architecture. In Drosophila, seamless tubes are...
- 9From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedThe transport of mRNAs allows gene expression to take place in both a spatially and temporally restricted manner (1-2). Found in a wide variety of cell types and organisms, from yeast to human, the process has diverse...
- 10From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedFbxw7[alpha] is a member of the F-box family of proteins, which function as the substrate-targeting subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes. Using differential purifications and mass...
- 11From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedChronic stress in the endoplasmic reticulum (ER) underlies many degenerative and metabolic diseases involving apoptosis of vital cells. A well-established example is autosomal dominant retinitis pigmentosa (ADRP), an...
- 12From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedSecretory proteins exit the endoplasmic reticulum in COPII-coated vesicles. Sec13 and Sec31 form the outer layer of the COPII coat and are thought to drive membrane curvature. Miller and colleagues present evidence that...
- 13From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedThe DNA-damage response (DDR) arrests cell-cycle progression until damage is removed. DNA-damage-induced cellular senescence is associated with persistent DDR. The molecular bases that distinguish transient from...
- 14From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedSubcellular localization of mRNAs by cytoskeletal motors plays critical roles in the spatial control of protein function (1). However, optical limitations of studying mRNA transport in vivo mean that there is little...
- 15From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedTumorigenesis involves the clonal growth of single cells harbouring oncogenic alterations within a normal tissue. Leung and Brugge reveal the mechanisms that allow such cells to escape the growth constraints imposed by...
- 16From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedOver the past 40 years my scientific pursuits have evolved along uncharted paths, guided by personal experiences, unexpected research findings and serendipity. The most recent turning point in my research interests was...
- 17From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedHumans suffer from high rates of fetal aneuploidy, often arising from the absence of meiotic crossover recombination between homologous chromosomes (1). Meiotic recombination is initiated by double-strand breaks (DSBs)...
- 18From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedCellular senescence is a stable proliferation arrest activated by diverse cellular stresses (1,2). As well as being proliferation-arrested, senescent cells secrete a complex mix of cell growth regulatory factors,...
- 19From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedEpithelial-mesenchymal transition (EMT), which is characterized by the suppression of the adhesion protein E-cadherin, is a crucial process that promotes metastasis and stem-like properties of cancer cells. However, the...
- 20From: Nature Cell Biology. (Vol. 14, Issue 4) Peer-ReviewedSexual reproduction is an energetically expensive and risky undertaking that exposes genomes to many threats (1). However, it is extremely widespread, with more than 99% of all identified vertebrate species reproducing...