Showing Results for
- Academic Journals (24)
Search Results
- 24
Academic Journals
- 24
- Search Terms:ISSN: 14655411AndISSN: 1465542XAndVolume Number: 14AndIssue Number: 4AndStart Page: R100AndDate: 2012 Revise Search
- 1From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Mammographic density (MD) is a strong, independent risk factor for breast cancer, but measuring MD is time consuming and reader dependent. Objective MD measurement in a high-throughput fashion would...
- 2From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction The receptor activator of nuclear factor-kB (NF-kB) (RANK)/receptor activator of NF-kB ligand (RANKL) axis emerges as a key regulator of breast cancer initiation, progression and metastasis. RANK...
- 3From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Transforming growth factor beta (TGF-[beta]) has a dual role during tumor progression, initially as a suppressor and then as a promoter. Epithelial TGF-[beta] signaling regulates fibroblast recruitment...
- 4From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Molecular apocrine is a subtype of estrogen receptor (ER)-negative breast cancer that is characterized by a steroid-response gene signature. We have recently identified a positive feedback loop between...
- 5From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction It has been demonstrated that the interplay of adhesion molecule CD44 and its ligands can regulate cancer cell proliferation, migration and invasion, as well as tumor-associated angiogenesis and is...
- 6From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target gene promoters via interactions with...
- 7From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Retinoic acid signaling plays key roles in embryonic development and in maintaining the differentiated status of adult tissues. Recently, the nuclear retinoic acid receptor (RAR) isotypes [alpha], [beta]...
- 8From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction We hypothesised that breast cancer risk for relatives of women with early-onset breast cancer could be predicted by tumour morphological features. Methods We studied female first-degree relatives...
- 9From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition (EMT) and exhibiting stem/progenitor cell...
- 10From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction The purpose of this investigation was to evaluate the efficacy of cisplatin chemotherapy in BRCA1 mutation carriers with metastatic breast cancer. Methods In a phase II, open-label study, 20...
- 11From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Recent studies reported that human IgG antibodies are susceptible to specific proteolytic cleavage in their lower hinge region, and the hinge cleavage results in a loss of Fc-mediated effector functions....
- 12From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Breast density is one of the strongest risk factors for breast cancer, but determinants of breast density in young women remain largely unknown. Methods Associations of height, adiposity and body...
- 13From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Angiogenesis represents a potential therapeutic target in breast cancer. However, responses to targeted antiangiogenic therapies have been reported to vary among patients. This suggests that the tumor...
- 14From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction There is a multitude of assays for the detection of circulating tumor cells (CTCs) but a very limited number of studies comparing the clinical relevance of results obtained with different test methods....
- 15From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Anti-estrogen therapy has been shown to reduce mammographic breast density (MD). We hypothesized that a short-term change in breast density may be a surrogate biomarker predicting response to adjuvant...
- 16From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Lobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade...
- 17From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Mutations in BRCA1 and BRCA2 confer a high risk of breast cancer (BC), but the magnitude of this risk seems to vary according to the study and various factors. Although controversial, there are data to...
- 18From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Gene amplification is an important mechanism for activating oncogenes in malignant tumors. Although amplification of HER2, C-MYC, CCND1 and FGFR1 has been reported in breast cancers, their role in the...
- 19From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Epigenetic events are, along with genetic alteration, important in the development and progression of cancer. Promoter hypermethylation causes gene silencing and is thought to be an early event in...
- 20From: Breast Cancer Research. (Vol. 14, Issue 4) Peer-ReviewedIntroduction Gene expression data derived from clinical cancer specimens provide an opportunity to characterize cancer-specific transcriptional programs. Here, we present an analysis delineating a correlation-based...