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- Search Terms:ISSN: 14655411AndISSN: 1465542XAndVolume Number: 14AndIssue Number: 3AndStart Page: 309AndDate: 2012 Revise Search
- 1From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction miRNAs are very important regulators in biological processes such as development, cellular differentiation, and carcinogenesis. Given the important role of miRNAs in tumorigenesis and development, it is...
- 2From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Progesterone receptors (PR) are emerging as important breast cancer drivers. Phosphorylation events common to breast cancer cells impact PR transcriptional activity, in part by direct phosphorylation....
- 3From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have...
- 4From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast...
- 5From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Of the more than one million global cases of breast cancer diagnosed each year, approximately fifteen percent are characterized as triple-negative, lacking the estrogen, progesterone, and Her2/neu...
- 6From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Basal-like breast cancers (BL-BCa) have the worst prognosis of all subgroups of this disease. Hyaluronan (HA) and the HA receptor CD44 have a long-standing association with cell invasion and metastasis...
- 7From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of...
- 8From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene...
- 9From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Tumor-associated macrophages, which are derived from the infiltration of circulating bone marrow-derived monocytes, consist primarily of a polarized M2 macrophage (M2-MÏ) population and are...
- 10From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction We examined the prognostic value of biologic subtype on locoregional recurrence (LRR) after mastectomy in a cohort of low risk women who did not receive adjuvant radiation therapy. Methods A total...
- 11From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction The majority of deaths from breast cancer are a result of metastases; however, little is understood about the genetic alterations underlying their onset. Genetic profiling has identified the adhesion...
- 12From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Human 17beta-hydroxysteroid dehydrogenase type 1 (17[beta]-HSD1) is a steroid-converting enzyme that has long been known to play critical roles in estradiol synthesis and more recently in...
- 13From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Experimental and clinical evidence points to a critical role of progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland tumorigenesis. However, the molecular mechanisms of...
- 14From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction We developed an analytic strategy that correlates gene expression and clinical outcomes as a means to identify novel candidate oncogenes operative in breast cancer. This analysis, followed by functional...
- 15From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction The underlying pathogenic mechanism of a large fraction of DNA variants of disease-causing genes is the disruption of the splicing process. We aimed to investigate the effect on splicing of the BRCA2...
- 16From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Overexpression of the human epidermal growth factor receptor 2 (HER2) as a result of HER2 gene amplification is associated with a relatively poor prognosis in breast cancer and is predictive of...
- 17From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Although development of anoikis-resistant myofibroblasts during tissue remodeling is known to be associated with tumor invasion, the mechanism by which myofibroblasts become resistant to anoikis is...
- 18From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction CT10 regulator of kinase (Crk) adaptor proteins (CrkI, CrkII and CrkL) play a role in integrating signals for migration and invasion of highly malignant breast cancer cell lines. This has important...
- 19From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction Tamoxifen is an effective treatment for breast cancer but an undesirable side-effect is an increased risk of endometrial cancer, particularly rare tumor types associated with poor prognosis. We...
- 20From: Breast Cancer Research. (Vol. 14, Issue 3) Peer-ReviewedIntroduction The majority of breast tumors at primary diagnosis are estrogen receptor positive (ER+). Estrogen (E) mediates its effects by binding to the ER. Therapies targeting the estrogenic stimulation of tumor...