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- 1From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedOxidative damage and inflammation are postulated to be involved in age-related macular degeneration (AMD). However, the molecular signal(s) linking oxidation to inflammation in this late-onset disease is unknown. Here we...
- 2From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedThe vital role of regulatory T ([T.sub.reg]) cells in maintaining self-tolerance is exquisitely clear (1). Defects in [T.sub.reg] cell development lead to systemic autoimmunity and early death in both mice and humans....
- 3From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedThe dendritic cell immunoreceptor (official gene symbol Clec4a2, called Dcir here) is a C-type lectin receptor expressed mainly in dendritic cells (DCs) that has a carbohydrate recognition domain in its extracellular...
- 4From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedAllergic asthma is a chronic disease characterized by airway obstruction in response to allergen exposure. It results from an inappropriate T helper type 2 response to environmental airborne antigens and affects 300...
- 5From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedMutations in the tumor suppressor p53 in cells surrounding a tumor--and not in the cancer cells themselves--is predictive of metastasis status, according to a study of individuals with breast cancer. Tumor-associated...
- 6From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedRhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to the development of effective...
- 7From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedA news story about the firing of Texas Tech University founding dean Robert Suskind (Nature Med. 13, 1392; 2007) mistakenly reported that he was dean of the Chicago Medical School at Rosalind Franklin University of...
- 8From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedInsulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin (1), but other substrates of the insulin receptor kinase, such as Gabl, c-Cbl, SH2-B and APS, are also of physiological relevance...
- 9From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedAbout 3,000 individuals in the United States are awaiting a donor heart; worldwide, 22 million individuals are living with heart failure. A bioartificial heart is a theoretical alternative to transplantation or...
- 10From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedThe drug Avastin has made headlines in recent years for its ability to treat colon and lung cancers. But when the South San Francisco-based biotechnology company Genentech, which developed Avastin, revealed plans in...
- 11From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedIf you want to raise lean, healthy children, it's best to shed those extra pounds before becoming pregnant. That's the implication of a study in rats examining how the environment of the womb can influence the weight of...
- 12From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedA dip in the hot tub--"heat therapy"--can improve insulin sensitivity in individuals with diabetes. Jason Chung et al. examine the mechanistic basis for this effect and home in on a new drug target (Proc. Natl. Acad....
- 13From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedTreacher Collins syndrome (TCS) is a congenital disorder of craniofacial development arising from mutations in TCOF1, which encodes the nucleolar phosphoprotein Treacle. Haploinsufficiency of Tcof1 perturbs mature...
- 14From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedVaccinated: One Man's Quest to Defeat the World's Deadliest Diseases Paul Offit Harper Collins, 2007 272 pp., hardcover, $26.95 ISBN 9780061227950 Vaccines have proven to be one of the most important and...
- 15From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedBreast milk protects young mice from developing symptoms of asthma. The effect occurs through the induction of regulatory T cells after ingestion of allergen and TGF-β in breast milk (pages 170-175). No clear...
- 16From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedAbout 3,000 individuals in the United States are awaiting a donor heart; worldwide, 22 million individuals are living with heart failure. A bioartificial heart is a theoretical alternative to transplantation or...
- 17From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedA new approach to pain relief may lead to drugs that kill chronic pain without side effects such as sedation. The approach involves selectively targeting [GABA.sub.A] receptors that contain specific subunits (Nature 451,...
- 18From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedA few weeks ago, a reader of our blog, Spoonful of Medicine, wondered what we meant by 'perceived' conflicts of interest: "This term crops up frequently in the editorials of Nature journals, and I would be extremely...
- 19From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedLittle progress has been made toward the use of embryonic stem (ES) cells to study and isolate skeletal muscle progenitors. This is due to the paucity of paraxial mesoderm formation during embryoid body (EB) in vitro...
- 20From: Nature Medicine. (Vol. 14, Issue 2) Peer-ReviewedDec 19 A survey of more than 2,000 teens between the ages of 15 and 19 found that boys and girls who received formal sex education before turning 15 were 71% and 59% less likely, respectively, to have sex before age 15...