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- 1From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedIn this study, we analyzed a "variant of uncertain significance" (VUS) located in exon 23 of the BRCA2 gene exhibited by six members of five distinct families with hereditary breast cancer (BC). The variant was...
- 2From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedDoctors commonly use genomic testing for breast cancer recurrence risk. We sought to assess whether the standard genomic report provided to doctors is a good approach for communicating results to patients. During...
- 3From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedResistance to endocrine therapy is a major complication of luminal breast cancer and studies of the biological features of hormonal resistance are limited by the lack of adequate preclinical models. The aim of this...
- 4From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedWe tested the hypothesis that genes involved in the alcohol oxidation pathway modify the association between alcohol intake and breast cancer. Subjects were women aged 55-74 at baseline from the screening arm of the...
- 5From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedInvasive lobular carcinoma (ILC) is the most common "special type" of breast cancer. Although conflicting literature data are available on the outcome of ILC, recently reported data indicate that ILC carries a poorer...
- 6From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedWe have determined the effect of combining the chemotherapy agent doxorubicin and the anti-resorptive drug zoledronic acid on the early stages of spontaneous mammary tumour development using the immunocompetent PyMT...
- 7From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedVascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and thereby involved in the development and progression of solid tumours. The association between polymorphisms of angiogenesis pathway...
- 8From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedBreast cancer is the leading cause of cancer-related deaths in women. Altered cellular functions of cancer cells lead to uncontrolled cellular growth and morphological changes. Cellular biomembranes are intimately...
- 9From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedThe purpose is to evaluate sensitivity of basal-like breast cancer to treatment with anti-DR5 alone and in combination with chemotherapy. Cytotoxicity of TRA-8 anti-DR5 alone and in combination with doxorubicin or...
- 10From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedTo compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. The...
- 11From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedFlat epithelial atypia (FEA) is a borderline lesion that might represent an early stage in the development of certain low-grade carcinomas in situ and invasive cancers. There are no guidelines on its management. Our...
- 12From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedAngiogenesis is important for the growth and spread of malignant tumors, and anti-angiogenesis treatment is currently being evaluated for breast cancer and other tumors. Although microvessel density is the most commonly...
- 13From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedThe sphingolipid ceramide is known to play a central role in chemo- and radiation-induced cell death. Acid ceramidase (AC) hydrolyzes ceramide, and thus reduces intracellular levels of this proapoptotic lipid. The role...
- 14From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedThe aim of this study was to determine whether an exercise program, commencing 4-6 weeks post-operatively, reduces upper limb impairments in women treated for early breast cancer. Women (n = 160) were randomized to...
- 15From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedBreast cancer stem cells (BrCSC) are resistant to common therapeutic modalities including chemotherapy, radiation, and hormonal agents. They are thought to contribute to treatment resistance, relapse, and metastases....
- 16From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedTo the Editor, The NBN (formerly NBS1) gene (OMIM*602667) is located on chromosome 8q21 and encodes a 754-amino acid protein known as nibrin. Nibrin is a component of the MRE11/RAD50/NBN (MRN) complex and is involved...
- 17From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedThe rearranged during transfection/papillary thyroid carcinoma (RET/PTC) tyrosine kinase is an oncogene implicated in the tumorigenesis of thyroid cancer. Recent studies by us and others have shown that RET/PTC kinase...
- 18From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedThe 70-gene prognosis-signature is validated as a good predictor of recurrence for hormone receptor-positive (ER+), lymph node-negative (LN-), human epidermal growth factor receptor type 2-negative (HER2-) early stage...
- 19From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedTriple-negative breast cancer (TNBC) is a heterogeneous disease that is usually associated with poor prognosis, and frequently associated with the basal-like breast cancer gene expression profile. There are no targeted...
- 20From: Breast Cancer Research and Treatment. (Vol. 133, Issue 2) Peer-ReviewedOver 200,000 women are diagnosed with breast cancer each year in the United States, and more than 80% are alive 10 years after diagnosis [1]. Treatment generally includes surgery, radiation therapy, chemotherapy, and/or...