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- 1From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedDespite extensive analysis of the BRCAI and BRCA2 genes, germline mutations are detected in <20% of families with a presumed genetic predisposition for breast and ovarian cancer. Recent literature reported RAD51C as a...
- 2From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedChemotherapy is widely used to treat early stage breast cancer (ESBC). Reductions and delays in dose administered--e.g., due to advanced age or febrile neutropenia (FN)--are generally believed to increase risk of...
- 3From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedVN/14-1 [4-([+ or -])-(1H-Imidazol-1-yl)-(E)-retinoic acid], a novel retinoic acid metabolism blocking agent (RAMBA), works by inhibiting the breakdown of all-trans-retinoic acid. The purpose of this study was to...
- 4From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedEpithelial mesenchymal transition (EMT) plays an important role in the development of metastases. One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by transcription...
- 5From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedRecent breast cancer treatment studies conducted in large urban settings have reported racial disparities in the appropriate use of adjuvant chemotherapy. This article presents the first focused evaluation of...
- 6From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedThough larger social networks are associated with reduced breast cancer mortality, there is a need to clarify how both social support and social burden influence this association. We included 4,530 women from the...
- 7From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedNEWEST (Neoadjuvant Endocrine Therapy for Women with Estrogen-Sensitive Tumors) is the first study to compare biological and clinical activity of fulvestrant 500 versus 250 mg in the neoadjuvant breast cancer setting....
- 8From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedOnly few case reports describe the pregnancy course and outcome of breast cancer patients, who were under treatment with trastuzumab at the time of conception or who have completed trastuzumab therapy before becoming...
- 9From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedErratum to: Breast Cancer Res Treat (2011) 129:37-47 DOI 10.1007/s10549-010-1177-4 The original publication of the article includes figures of lower resolution. The author would like to correct this with the...
- 10From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedThe insulin-like growth factor (IGF) axis is fundamentally important in cell growth, development and cancer. We used genomic technologies to better characterize the activity of the IGF axis in human breast cancer and to...
- 11From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedRadiotherapy is a treatment choice for local control of breast cancer, particularly after the removal of tumor tissues by surgery. However, intrinsic radioresistance of cancer cells limits therapeutic efficacy. Here, we...
- 12From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedErratum to: Breast Cancer Res Treat DOI 10.1007/s10549-011-1753-2 The original publication of the article has been published with incorrect values in table row "Y419/Total Src" pertaining to Fig. 1, part b. The...
- 13From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedPlacenta growth factor (PlGF) and vascular endothelial growth factor A (VEGF-A) are angiogenic growth factors interacting competitively with the same receptors. VEGF-A is essential in both normal and pathologic...
- 14From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedSeveral adverse effects of chemotherapy treatments have been described, and most of these effects are associated with direct interactions between blood cells and indirect effects generated during the oxidative...
- 15From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedDeleterious mutations in several genes that are involved in repair of damage to DNA have been associated with an increased risk of breast cancer. Recent studies have shown sequence variants in two such genes, RAD50 and...
- 16From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedThere is limited evidence on the role of 3D mammography with tomosynthesis in breast screening, although early studies suggest that it may improve specificity. We prospectively evaluated the effect of integrating 3D...
- 17From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedCytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of...
- 18From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedInvestigations of breast carcinogenesis often rely upon comparisons between cancer tissue and nonmalignant breast tissue. It is unclear how well common reference sources of nonmalignant breast tissues reflect normal...
- 19From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedAdherence to long-term pharmacological treatment for chronic conditions is often less than optimal. Till date, a limited number of population-based studies have assessed adherence to adjuvant hormonal therapy in breast...
- 20From: Breast Cancer Research and Treatment. (Vol. 133, Issue 1) Peer-ReviewedLimiting tumor invasion to the surrounding healthy tissues has proven to be clinically relevant for anticancer treatment options. We have demonstrated that, within a solid tumor, it is possible to achieve such a goal...