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- 1From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedTamoxifen decreases breast cancer recurrence, mortality, and breast cancer risk in high-risk women. Despite these proven benefits, tamoxifen use is often limited due to side effects. We identified predictors of...
- 2From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedFunctional development of the mammary gland is an important physiological process. Several studies have used gene expression profiling of mammary gland development to identify the key genes in the process, but few...
- 3From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedHigh mammographic density (MD) is used as a phenotype risk marker for developing breast cancer. During pregnancy and lactation the breast attains full development, with a cellular-proliferation followed by a...
- 4From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedIn the last decades, several gene expression-based predictors of clinical behavior were developed for breast cancer. A common feature of these is the use of multiple genes to predict hormone receptor status and the...
- 5From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedCirculating estrogens are an established risk factor for breast cancer and some data suggest that diet may influence estrogen levels. Therefore, using a subsample (n = 550) of women from a large cohort, we applied...
- 6From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedClinicians can use biomarkers to guide therapeutic decisions in estrogen receptor positive (ER+) breast cancer. One such biomarker is cellular proliferation as evaluated by Ki-67. This biomarker has been extensively...
- 7From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedThe aim of this study was to investigate the association of two genetic polymorphisms, MDM2 SNP309 and TP53 R72P, with incidence of neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide...
- 8From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedComprehensive genetic testing of the breast cancer susceptibility genes BRCA1 and BRCA2 identified approximately 16% of variants of unknown significance (VUS), a significant proportion of which could affect the correct...
- 9From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-Reviewed
US follow-up protocol in concordant benign result after US-guided 14-gauge core needle breast biopsy
To determine the time when follow-up ultrasound (US) should begin for concordant benign lesions after US-guided 14-gauge core needle breast biopsy (CNB). This was an IRB-approved retrospective study, with a waiver of... - 10From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedLapatinib, a dual kinase inhibitor against epidermal growth factor receptor (EGFR) and human epidermal receptor two (HER2) has shown efficacy in treating HER2 positive breast cancer. Nanoparticle albumin bound (nab)...
- 11From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedA limited number of studies have associated adjuvant chemotherapy with structural brain changes. These studies had small sample sizes and were conducted shortly after cessation of chemotherapy. Results of these studies...
- 12From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedCo-amplification of the centromere on chromosome 17 (CEP17) and HER2 can occur in breast cancer. Such aberrant patterns (clusters) on CEP17 can be misleading to calculate the HER2/CEP17 ratio, and thus underreporting of...
- 13From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedIn a retrospective study, we investigated the reasons why women accepted to undergo a nipple sparing mastectomy (NSM) and why women who could not keep their nipple areola complex (NAC) decided to reconstruct it. We...
- 14From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedObesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelerate tumor...
- 15From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedNeoadjuvant chemotherapy for breast cancer allows individual tumor response to be assessed depending on molecular subtype, and to judge the impact of response to therapy on recurrence-free survival (RFS). The...
- 16From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedResponse assessment by imaging methods has always been considered not precise enough and not sufficiently correlated with outcome of patients. In opposite, response assessment by pathological examination was considered...
- 17From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedMammographic density is strongly and consistently associated with breast cancer risk. To determine if this association was modified by reproductive factors (parity and age at first birth), data were combined from four...
- 18From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedGermline mutations in BRCAI were already linked to basal-like subtype of immunophenotypic molecular classification of breast cancer (BC). However, it is not known whether mutations in other BC susceptibility genes are...
- 19From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedThis two-arm randomized clinical study aimed to evaluate the efficacy and safety of neoadjuvant concurrent chemotherapy and letrozole in postmenopausal women with locally advanced breast carcinoma. One hundred and one...
- 20From: Breast Cancer Research and Treatment. (Vol. 132, Issue 3) Peer-ReviewedHypersensitivity to radiation exposure has been suggested to be a risk factor for the development of breast cancer. In this case-control study of 515 young women ([less than or equal to] 55 years) with newly diagnosed...