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- 1From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedDrug addiction involves long-lasting adaptations in the brain's reward circuitry, mediated in part by alterations in gene expression (1). This month's issue of Nature Neuroscience contains two reports implicating methyl...
- 2From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedDespite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus...
- 3From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedOne fundamental principle of many sensory systems is that they are highly organized. The mammalian retina, for example, has a smooth representation of visual position that is achieved by intricate mosaic tiling of...
- 4From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-Reviewed
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its role in the neurodevelopmental disorder Rett syndrome, is emerging as an important regulator of neuroplasticity in postmitotic... - 5From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedAfter a salient experience, we rapidly consolidate the memory for that experience, allowing critical information to be retained long after the experience has passed. Addiction to drugs of abuse is considered to be a...
- 6From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedParvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that [GABA.sub.A] receptor-mediated synaptic inputs from...
- 7From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedBreathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBotzinger complex (preBotC), which paces...
- 8From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedIt has been suggested that gene expression and protein synthesis are required for both long-term memory consolidation and late phases of long-term potentiation and long-term depression (LTD). The necessary genes and the...
- 9From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedThe preBotzinger complex (preBotC) is a critical component of the respiratory rhythm-generator that underlies mammalian breathing. However, we know little about the developmental origins of its neurons or the molecular...
- 10From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedProlonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. We found that a similar form of functional antagonism was...
- 11From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedSelective expression of retinal cone opsin genes is essential for color vision, but the mechanism mediating this process is poorly understood. Both vertebrate rod and medium wavelength-sensitive (M) cone photoreceptors...
- 12From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedAKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory...
- 13From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedIn mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion cells (ipRGCs). Circadian...
- 14From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedDespite the essential role of the corticospinal tract (CST) in controlling voluntary movements, successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion has never been achieved. We found...
- 15From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedVisual cortex shows smooth retinotopic organization on the macroscopic scale, but it is unknown how receptive fields are organized at the level of neighboring neurons. This information is crucial for discriminating...
- 16From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedWisdom: From Philosophy to Neuroscience by Stephen S Hall Alfred A. Knopf, New York, 2010 352 pages, $27.95 ISBN 978-0307269102 We all want it, few of us have it, we don't know what it is, but we are...
- 17From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedHomeostatic synaptic scaling alters the strength of synapses to compensate for prolonged changes in network activity and involves both excitatory and inhibitory neurons. The immediate-early gene Narp (neuronal...
- 18From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedWe found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger...
- 19From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedThis July, a PepsiCo-sponsored blog at the popular science website Scienceblogs.com was canceled two days after its launch because of mounting discontent from other independent scientific bloggers. The blog, Food...
- 20From: Nature Neuroscience. (Vol. 13, Issue 9) Peer-ReviewedWe found the voltage-gated [K.sup.+] channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing...