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- 1From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedA substantial proportion of patients with breast cancer develop distant metastases after years and sometimes even decades of latency. Mina Bissell and colleagues have found that the expression of thrombospondin 1 by...
- 2From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedTimes have changed: gone are the days when flow cytometry involved just a few markers for analysis. With the advent of mass cytometry that takes advantage of isotope-conjugated antibodies, dozens of parameters can be...
- 3From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedFusion genes that are caused by chromosome translocations have been recognized for several decades as drivers of deregulated cell growth in certain types of cancer. In recent years, oncogenic fusion genes have been...
- 4From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedMutations in the tumour suppressor protein p53 do not always result in a loss of function; some mutants have a gain of function (GOF). Moshe Oren and colleagues found that expression of the R273H p53 GOF mutant in a...
- 5From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedTwo recent papers have provided evidence that the mitochondrial sirtuin SIRT4 exerts tumour suppressive activities by repressing glutamine metabolism. Jeong, Xiao et al. examined the metabolic response to DNA damage,...
- 6From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedCells in solid tumours experience various fluctuations in their microenvironment, including changes in the availability of oxygen. Celeste Simon and colleagues have found that, under hypoxic conditions, tumour cells in...
- 7From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedGermline mutations of either BRCA1 or BRAC2 are particularly associated with an increased risk for breast and ovarian cancer. The initial results of a Phase I/II trial reported at the annual meeting of the American...
- 8From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedSince the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the...
- 9From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedCancer cells are subject to many apoptotic stimuli that would kill them were it not for compensatory prosurvival alterations. BCL-2-like (BCL-2L) proteins contribute to such aberrant behaviour by engaging a network of...
- 10From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedOverexpression of oncogenic RAS has been shown to cause macropinocytosis, which is a type of endocytosis used by cells to take in extracellular fluid and its contents. Whether this process has any functional...
- 11From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedForkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This...
- 12From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedConnections between metabolic disruption and altered epigenetic modifications are increasingly being realized in cancer. Much attention has focused on DNA hypermethylation that results from the mutation of isoforms of...
- 13From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedA Jack of all trades' is one phrase that has been used to describe p53, the most recently identified function of which has been the regulation of various aspects of cell metabolism, but is this regulation linked to the...
- 14From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedThe concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that...
- 15From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedNature Reviews Cancer 13, 425-431 (2013) In Table 1 of this article, the [beta]3 integrin row should have read "523-544 and 560-583" in the "Disulphide cysteines" column and "--RHstaple and--LHhook (3IJE)" in the...
- 16From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedAlthough at the genetic level cancer is caused by diverse mutations, epigenetic modifications are characteristic of all cancers, from apparently normal precursor tissue to advanced metastatic disease, and these...
- 17From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedBlocking inhibitory immune checkpoint proteins in cancer patients has already proved to have some efficacy in the clinic: the antibody ipilimumab (which targets cytotoxic T lymphocyte-associated antigen 4 (CTLA4), a...
- 18From: Nature Reviews Cancer. (Vol. 13, Issue 7) Peer-ReviewedA paper published in Nature Communications reports that the topoisomerase II inhibitors doxorubicin and daunorubicin induce histone eviction from open chromatin. This effect was independent of the induction of DNA...