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- 1From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedRecent neuroimaging and postmortem studies have reported abnormalities in white matter of schizophrenic brains, suggesting the involvement of oligodendrocytes in the etiopathology of schizophrenia. This view is being...
- 2From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedG72 is a strong candidate susceptibility gene for schizophrenia and bipolar disorder, whose function remains enigmatic. Here we show that one splicing isoform of the gene (LG72) encodes for a mitochondrial protein. We...
- 3From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedComplex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene-gene interactions are incompletely understood. 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the...
- 4From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedD-amino acid oxidase (DAO or DAAO) metabolizes the N-methyl D-aspartate receptor (NMDAR) modulator D-serine. (1) Enhanced DAO activity is, thus, a potential cause of reduced D-serine and thence impaired NMDAR functioning...
- 5From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedSeveral lines of evidence implicate the pro-inflammatory cytokine interleukin-1 (IL-1) in the etiology and pathophysiology of major depression. To explore the role of IL-1 in chronic stress-induced depression and some of...
- 6From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedRecent advances in high-throughput genotyping now permit genome-wide association studies (GWASs) in which hundreds of thousands of DNA polymorphisms spread across the genome can be assayed in a large set of individuals...
- 7From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedQuantitative genetic research suggests that reading disability is the quantitative extreme of the same genetic and environmental factors responsible for normal variation in reading ability. This finding warrants a...
- 8From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedSchizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final identification...
- 9From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedDeciphering sensory gating mechanisms may give clues to some of the neurophysiological deficits present in mental disorders. Here, we report an alteration of prepulse inhibition (PPI) and dendrite abnormalities of the...
- 10From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedBoth the MET allele of va166met BDNF and the S allele of 5-HTTLPR affect regional brain volume, measured by voxel-based morphometry and magnetic resonance imaging. Middle row: These two risk variants interact...
- 11From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedSpouse abuse, listed as a V code (V61.12) in DSM-IV, has been viewed almost exclusively from a social perspective. In this functional magnetic resonance imaging (fMRI) study, we observed that batterers, relative to...
- 12From: Molecular Psychiatry. (Vol. 13, Issue 7) Peer-ReviewedPhospholipase C-β1 (PLC-β1) is a rate-limiting enzyme implicated in postnatal-cortical development and neuronal plasticity. PLC-β1 transduces intracellular signals from specific muscarinic, glutamate and serotonin...