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- 1From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedGenome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population M Liao, F Ye, B Zhang, L Huang, Q Xiao, M Qin, L Mo, A Tan, Y Gao, Z Lu, C Wu, Y...
- 2From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedThe mammalian cell entry (Mce)1 protein complex has an important role during the initial phase of a Mycobacterium tuberculosis (M. tuberculosis) infection. Murine macrophages were infected with M. tuberculosis H37Rv or...
- 3From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedIgG has a crucial role in humoral immune response. Serum IgG level is mainly determined under genetic control. To explore the genetic influence on serum IgG levels, a two-stage genome-wide association study (GWAS) was...
- 4From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedThe mBin1b is a beta-defensin gene identified in the mouse epididymis. In the current report, its expression pattern and antibacterial activities were characterized, and a transgenic (TG) mouse model was developed in...
- 5From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedSusceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied...
- 6From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedSome genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's...
- 7From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedThe HLA genomic structure underlines the permanence of fixed haplotypes transmitted in blocks as allelic combinations. One of the most discussed concerns is how and why such a strong linkage between HLA alleles has been...
- 8From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedCeliac disease (CD) is a T-cell-mediated chronic inflammatory disease characterized by autoimmune, immunological and environmental components, where genetic factors in addition to the main known risk factors (gliadin...
- 9From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedThere is increasing evidence that gene copy number (CN) variation influences clinical phenotype. The low-affinity Fc receptor 3B (FCGR3B) located in the FCGR gene cluster is a CN polymorphic gene involved in the...
- 10From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedVast diversity in the antibody repertoire is a key component of the adaptive immune response. This diversity is generated centrally through the assembly of variable, diversity and joining gene segments, and peripherally...
- 11From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedCertain groups of physically linked genes remain linked over long periods of evolutionary time. The general view is that such evolutionary conservation confers 'fitness' to the species. Why gene order confers 'fitness'...
- 12From: Genes and Immunity. (Vol. 13, Issue 6) Peer-ReviewedThe genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide...