Showing Results for
- Academic Journals (14)
Search Results
- 14
Academic Journals
- 14
- Search Terms:
- 1From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedAdvances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these...
- 2From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedIntroduction Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and...
- 3From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedIntroduction Tumor-initiating cells (TIC) are being extensively studied for their role in tumor etiology, maintenance and resistance to treatment. The isolation of TICs has been limited by the scarcity of this...
- 4From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedIntroduction Both the percent of mammographic density and absolute dense (fibroglandular) area are strong breast cancer risk factors. The role of non-dense (fat) breast tissue is not often investigated, but we...
- 5From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedRecent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical...
- 6From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedSTAT5 consists of two proteins, STAT5A/B, that impact mammary cell differentiation, proliferation, and survival. In normal development, STAT5 expression and activity are regulated by prolactin signaling with JAK2/ELF5,...
- 7From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedMutation of p53 occurs in 15 to 20% of all breast cancers, and with higher frequency in estrogen-receptor negative and high-grade tumors. Certain p53 mutations contribute to malignant transformation not only through...
- 8From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedMale breast carcinoma is a rare condition. Few male breast cancer-specific epidemiological or clinical trial data are available - our understanding of male breast cancer thus comes from studies of female breast cancer,...
- 9From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedTumor cell dissemination in bone marrow or other organs is thought to represent an important step in the metastatic process. The detection of bone marrow disseminated tumor cells is associated with worse outcome in...
- 10From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedIntroduction Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively. BCI...
- 11From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedThe hereditary breast and ovarian cancer predisposition genes BRCA1 and BRCA2 account for the lion's share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective...
- 12From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedThe meeting of the European Network for Breast Development and Cancer (ENBDC) on 'Methods in Mammary Gland Development and Cancer' has become an annual international rendezvous for scientists with interests in the...
- 13From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedIntroduction Skeletal metastases from breast adenocarcinoma are responsible for most of the morbidity and mortality associated with this tumor and represent a significant and unmet need for therapy. The arrival of...
- 14From: Breast Cancer Research. (Vol. 13, Issue 5) Peer-ReviewedBackground Inherited mutations in the BRCA2 gene greatly increase the risk of developing breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair, complex genomic changes are frequently...