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- 1From: Arthritis Research & Therapy. (Vol. 13, Issue Suppl 2) Peer-ReviewedAuthor(s): Gerd R Burmester1, Peter E Lipsky2, Thomas Dörner2 and the Kitasato Meeting Faculty After successful meetings in 2009 and 2010, an international faculty of largely immunologists and rheumatologists will...
- 2From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was...
- 3From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction As a group, rheumatoid arthritis (RA) patients exhibit increased risk of infection, and those treated with anti-tumor necrosis factor (TNF) therapy are at further risk. This increased susceptibility may...
- 4From: Arthritis Research & Therapy. (Vol. 13, Issue 1) Peer-ReviewedIntroduction Hand osteoarthritis (OA) is associated with pain, reduced grip strength, loss of range of motion and joint stiffness leading to impaired hand function and difficulty with daily activities. The...
- 5From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Articular cartilage functions in withstanding mechanical loads and provides a lubricating surface for frictionless movement of joints. Osteoarthritis, characterised by cartilage degeneration, develops...
- 6From: Arthritis Research & Therapy. (Vol. 13, Issue 1) Peer-ReviewedIntroduction In this study, we sought to determine the diagnostic value and clinical laboratory associations of autoantibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in...
- 7From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren's syndrome (pSS). Plasma cells producing these...
- 8From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Mouse models of rheumatoid arthritis (RA) have proven critical for identifying genetic and cellular mechanisms of the disease. Upon discovering mice in our breeding colony that had spontaneously...
- 9From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Postural instability and falls are increasingly recognized problems in patients with fibromyalgia (FM). The purpose of this study was to determine whether FM patients, compared to age-matched healthy...
- 10From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as...
- 11From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Intervertebral disc tissue homeostasis is modulated by a variety of molecules. Silent mating type information regulator 2 homolog 1 (SIRT1) plays a key role in various physiological processes. The aim of...
- 12From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Systemic lupus erythematosus (SLE) patients have lower bone mineral density and increased fracture risk when compared with healthy individuals, due to distinct factors and mechanisms. Bone remodeling is...
- 13From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction The objective of this study was to investigate which genes are regulated by osteogenic protein-1 (OP-1) in human articular chondrocytes using Affimetrix gene array, in order to understand the role of...
- 14From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Traumatic joint injury damages cartilage and causes adjacent joint tissues to release inflammatory cytokines, increasing the risk of developing osteoarthritis. The main objective of this study was to...
- 15From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Janus kinase 2 (JAK2) is involved in the downstream activation of signal transducer and activator of transcription 3 (STAT3) and STAT5 and is responsible for transducing signals for several...
- 16From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines....
- 17From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction The presence of anti-topoisomerase I (topo I) antibodies is a classic scleroderma (SSc) marker presumably associated with a unique clinical subset. Here the clinical association of anti-topo I was...
- 18From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction The mono- and digalactosyldiacylglycerol (MGDG and DGDG) galactolipids have been purified from the thermophilic blue-green alga Phormidium sp. ETS-05 that colonizes the therapeutic thermal mud of Abano...
- 19From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction A consequence of knee joint osteoarthritis (OA) is an inability to fully activate the quadriceps muscles, a problem termed arthrogenic muscle inhibition (AMI). AMI leads to marked quadriceps weakness...
- 20From: Arthritis Research & Therapy. (Vol. 13) Peer-ReviewedIntroduction Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the...