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- Search Terms:ISSN: 14655411AndISSN: 1465542XAndVolume Number: 13AndIssue Number: 4AndStart Page: 217AndDate: 2011 Revise Search
- 1From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedIntroduction The presence of tumor cells in the axillary lymph nodes is the most important prognostic factor in early stage breast cancer. However, the optimal method for sentinel lymph node (SLN) examination is...
- 2From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedInhibitors of poly(ADP-ribose) polymerase (PARP)-mediated DNA repair have shown promise in early clinical studies in the treatment of specific subgroups of breast cancer. Notably, phase II trials indicate that olaparib,...
- 3From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedEpithelial to mesenchymal transition (EMT) is an essential process in embryonic development and is aberrantly induced in many disease settings. Work carried out by Chonghui Cheng's laboratory addressed the involvement...
- 4From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedCancer cells show a broad spectrum of bioenergetic states, with some cells using aerobic glycolysis while others rely on oxidative phosphorylation as their main source of energy. In addition, there is mounting evidence...
- 5From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedBreast cancer cells often respond to an endocrine therapy by altering expression of specific estrogen-responsive genes and inducing autophagy, a cannibalistic lysosomal pathway. Autophagy eliminates damaged or other...
- 6From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedIntroduction The ataxia-telangiectasia mutated (ATM) gene (MIM ID 208900) encodes a protein kinase that plays a significant role in the activation of cellular responses to DNA double-strand breaks through subsequent...
- 7From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedThe metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites...
- 8From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedBreast cancer is a complex and heterogeneous disease. Gene expression profiling has contributed significantly to our understanding of this heterogeneity at a molecular level, refining taxonomy based on simple measures...
- 9From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedAuthor(s): Andrea H Bild1,2 , Joel S Parker3,4 , Adam M Gustafson5 , Chaitanya R Acharya2 , Katherine A Hoadley3,4 , Carey Anders2 , P Kelly Marcom2 , Lisa A Carey3,7 , Anil Potti2 , Joseph R Nevins2 and Charles M...
- 10From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedIntroduction SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast...
- 11From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedDespite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially...
- 12From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedIntroduction Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)[alpha] functions and aromatase inhibitors that decrease local and...
- 13From: Breast Cancer Research. (Vol. 13, Issue 4) Peer-ReviewedPreclinical investigations and selected clinical observational studies support an association between higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk. However, the recently updated...