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- 1From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedOne of the reasons why we forget past experiences is because we acquire new memories in the interim. Although the hippocampus is thought to be important for acquiring and retaining memories, there is little evidence...
- 2From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedAfter a long week in the lab, you and your colleagues are having a drink in a nearby pub when suddenly your supervisor runs in and asks you whether you would be willing to write a News & Views article together. He gives...
- 3From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedOsmoregulated vasopressin release is facilitated during the late sleep period (LSP) to prevent dehydration and enuresis. Previous work has shown that clock neurons in the suprachiasmatic nucleus (SCN) have low firing...
- 4From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedRod photoreceptors in the mammalian retina allow vision under dim light conditions, when cones are not sufficiently activated. The rod light response, however, is relatively slow. Rods transmit their signals mainly to...
- 5From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedAnxiety disorders such as post-traumatic stress are characterized by an impaired ability to learn that cues previously associated with danger no longer represent a threat. However, the mechanisms underlying fear...
- 6From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedOne of the mysteries of life is that cells with identical genetic material maintain unique identities and specialized functions. This phenomenon is, in part, attributed to epigenetically controlled cellular memory, a...
- 7From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedPresynaptic [GABA.sub.A] receptors ([GABA.sub.A]Rs) occur at hippocampal mossy fiber synapses. Whether and how they modulate orthodromic signaling to postsynaptic targets is poorly understood. We found that an...
- 8From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedLocal interneurons are essential in information processing by neural circuits. Here we present a comprehensive genetic, anatomical and electrophysiological analysis of local interneurons (LNs) in the Drosophila...
- 9From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedDnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic neurons, but their function in the CNS is unclear. We generated conditional mutant mice that lack Dnmt1, Dnmt3a or both exclusively...
- 10From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedRod photoreceptors were recently shown to contact 'Off' cone bipolar cells, providing an alternative pathway for rod signal flow in the mammalian retina. By recording from pairs of rods and Off cone bipolar cells in the...
- 11From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedAttention is the process that selects which sensory information is preferentially processed and ultimately reaches our awareness. Attention, however, is not a unitary process; it can be captured by unexpected or salient...
- 12From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedExisting techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the...
- 13From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedAnyone who has ever experienced jet-lag knows that our bodies contain their own internal clock, which keeps us synchronized with the physical world and keeps our various physiological systems working together. How does...
- 14From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedMicroglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-[beta]. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease...
- 15From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedFaces and bodies are perhaps the most salient and evolutionarily important visual stimuli. Using human functional imaging, we found that the strength of face and body representations depends on long-term experience....
- 16From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedEstablishing the circuitry underlying attentional and oculomotor control is a long-standing goal of systems neuroscience. The macaque lateral intraparietal area (LIP) has been implicated in both processes, but numerous...
- 17From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedDo mice have empathy? This question may elicit a wide range of answers, including "yes, of course", "impossible" and "we'll never know". One of the reasons behind such a diversity of opinions is simply a matter of...
- 18From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedFear can be acquired vicariously through social observation of others suffering from aversive stimuli. We found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive...
- 19From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-Reviewed
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
A myriad of mechanisms have been suggested to account for the full richness of visual cortical plasticity. We found that visual cortex lacking Arc is impervious to the effects of deprivation or experience. Using... - 20From: Nature Neuroscience. (Vol. 13, Issue 4) Peer-ReviewedDoublesex proteins, which are part of the structurally and functionally conserved Dmrt gene family, are important for sex determination throughout the animal kingdom. We inserted Gal4 into the doublesex (dsx) locus of...