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- 1From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedOver 25 years ago, the disparate ways in which exogenously provided and endogenously synthesized influenza virus antigens seem to be processed and recognized in the context of major histocompatibility (MHC) class II and...
- 2From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedInterferons are a diverse family of cytokines with critical roles in immunity. In the Journal of Experimental Medicine, Quintana-Murci and colleagues use population genetics to delineate the relative importance of...
- 3From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedDelineating the mechanisms that lead to the production of bioactive interleukin 1[beta] (IL-1[beta]) has been the focus of intense research in the past few years. This pleotropic factor is critical in the...
- 4From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedNuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which...
- 5From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedInteractions driven by the T cell antigen receptor (TCR) determine the lineage fate of [CD4.sup.+][CD8.sup.+] thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are...
- 6From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedEffector and memory T cells show differences in their metabolic states and use of energy sources. In Immunity, Pearce and colleagues explore how [CD8.sup.+] T cells switch their metabolic state to become memory cells....
- 7From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedProduction of the proinflammatory cytokine interleukin 1b (IL-1[beta]) by dendritic cells is crucial in host defense. Here we identify a previously unknown role for dectin-1 in the activation of a noncanonical caspase-8...
- 8From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedInvasive infection with Salmonella is a common complication in people with malaria. In Nature Medicine, Riley and colleagues show that loss of resistance to Salmonella is due to the hemolytic release of heme and the...
- 9From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedThe human adaptive immune system relies heavily on casual encounters. Intravital microscopy has shown in tremendous detail how primed T cells survey their environment and bump into thousands of other cells in the...
- 10From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedThe surveillance of body barriers relies on resident T cells whose repertoires are biased toward particular [gamma][delta] T cell antigen receptors (TCRs) according to location. These [gamma][delta] TCRs can recognize...
- 11From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedIntrinsic antiviral immunity refers to a form of innate immunity that directly restricts viral replication and assembly, thereby rendering a cell nonpermissive to a specific class or species of viruses. Intrinsic...
- 12From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedAfter exposure to inflammatory signals, activation of the transcription factor NF-[kappa]B is needed to upregulate expression of antiapoptotic genes that confer cell survival. In Molecular Cell, Sen et al. show that TNF...
- 13From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedSAMHD1 restricts the infection of dendritic and other myeloid cells by human immunodeficiency virus type 1 (HIV-1), but in lentiviruses of the simian immunodeficiency virus of sooty mangabey (SIVsm)-HIV-2 lineage,...
- 14From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedTo the Editor: Ivermectin is a broad-spectrum antihelmintic drug used to treat pinworms and fur mites in laboratory mouse colonies. Here we report activation of a tamoxifen-regulated Cre recombinase fusion protein as...
- 15From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedThe cloning of the [gamma]-chain of the T cell antigen receptor (TCR) in 1984 provoked commotion because it was originally misidentified as a TCR [alpha]-chain (1) and because a second form of the TCR was not...
- 16From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedThe molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we demonstrate that in pre-B cells, the...
- 17From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedSystem-wide measurements of gene expression by DNA microarray and, more recently, RNA-sequencing strategies have become de facto tools of modern biology and have led to deep understanding of biological mechanisms and...
- 18From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedAutophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of...
- 19From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedThe growth factor GM-CSF is a pleiotropic cytokine with activatory properties for innate leukocytes and is believed to be produced mostly by non-hematopoietic cells and macrophages. In Science, Rauch et al. show that...
- 20From: Nature Immunology. (Vol. 13, Issue 3) Peer-ReviewedInterleukin 35 (IL-35) belongs to the IL-12 family of heterodimeric cytokines but has a distinct functional profile. IL-35 suppresses T cell proliferation and converts naive T cells into IL-35-producing induced...