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- 1From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedThe adult human heart lacks sufficient regenerative capacity to recover after a myocardial infarction. Cell-based therapy has emerged as a potential treatment for the failing heart; however, a key issue for the success...
- 2From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedCell growth can be suppressed by stressful environments, but the role of stress pathways in this process is largely unknown. Here we show that a cascade of p38β mitogen-activated protein kinase (MAPK) and...
- 3From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedStimulation of cells with epidermal growth factor (EGF) results in the ubiquitylation of multiple proteins, which can alter protein-protein interactions and modulate the direction and interaction of signalling pathways....
- 4From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedThe epithelial-mesenchymal transition (EMT) has recently been linked to stem cell phenotype (1,2). However, the molecular mechanism underlying EMT and regulation of stemness remains elusive. Here, using genomic...
- 5From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedAneuploidy is one of the most prevalent phenotypes of human tumours, but the underlying cause of this phenomenon remains highly debated. Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown...
- 6From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedTwo major mechanisms have been causally implicated in the establishment of cellular senescence: the activation of the DNA damage response (DDR) pathway and the formation of senescence-associated heterochromatic foci...
- 7From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedCompletion of genome duplication is challenged by structural and topological barriers that impede progression of replication forks. Although this can seriously undermine genome integrity, the fate of DNA with unresolved...
- 8From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedIn the version of this article initially published online and in print, the values for [k.sub.out] and [k.sub.in] in table 1 were incorrect. The correct values are (x[10.sup.-3] [s.sup.-1]). This error has been...
- 9From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedClathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively internalize molecules from the plasma membrane and surrounding environment. Previous live-cell imaging studies using ectopically...
- 10From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedPTEN is a tumour suppressor frequently lost or mutated in cancer. Cytoplasmic PTEN represses PI3K/Akt signalling through its phosphatase activity and limits cell growth. PTEN also localizes to the nucleus, but its...
- 11From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedCancer cells consume large quantities of glucose and primarily use glycolysis for ATP production, even in the presence of adequate oxygen (1,2). This metabolic signature (aerobic glycolysis or the Warburg effect)...
- 12From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedIn the last few years, repositories for imaging data hosted by laboratories, consortia and even journals have emerged. Image data stored in these repositories include spatial and temporal measurements of gene...
- 13From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedProgress through mitosis requires that the right protein be degraded at the right time. One ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) targets most of the crucial mitotic regulators by...
- 14From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedIt is well known that aged or senescent cells develop a complex senescence-associated secretory phenotype (SASP), which is observed both in culture and in vivo. However, the mechanisms underlying the induction of the...
- 15From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedThe ERK (extracellular signal-regulated kinase) MAPK (mitogen-activated protein kinase) cascade (Raf-MEK-ERK) mediates mitogenic signalling, and is frequently hyperactivated by Ras oncogenes in human cancer. The entire...
- 16From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedGlucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer cells. The tumour suppressor p53 has now been reported to block...
- 17From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedDuring development, a polarized epidermal sheet undergoes stratification and differentiation to produce the skin barrier. Through mechanisms that are poorly understood, the process involves actin dynamics, spindle...
- 18From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedClathrin coats assemble around nascent endocytic vesicles, but must be disassembled before vesicles can fuse with target membranes. Hsc70 (heat shock cognate protein-70) is important for this disassembly step. Using...
- 19From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedAneuploidy is common in human tumours and is often indicative of aggressive disease. Aneuploidy can result from cytokinesis failure, which produces binucleate cells that generate aneuploid offspring with subsequent...
- 20From: Nature Cell Biology. (Vol. 13, Issue 3) Peer-ReviewedIn response to major cellular insults, a massive increase in lysosomal membrane permeability (LMP) leads to necrosis. Data now reveal that this potent lysosomal-mediated necrotic cell-death machinery can also be...