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- 1From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedIn perceptual discrimination tasks, a subject's response time is determined by both sensory and motor processes. Measuring the time consumed by the perceptual evaluation step alone is therefore complicated by factors...
- 2From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedRegulated exocytosis is essential for many biological processes and many components of the protein trafficking machinery are ubiquitous. However, there are also exceptions, such as SNAP-25, a neuron-specific SNARE...
- 3From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedStaying organized is tough, but usually worth the effort. Even if you don't follow that maxim, your brain certainly seems to. Neural circuits are wired with marked accuracy, with neurons being capable of contacting...
- 4From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedNeural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials. Many studies have examined the effect of a stimulus on the mean response, but few have...
- 5From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedmRNA localization is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. To identify mRNAs localized in subcellular compartments of developing...
- 6From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedWe found that demyelinated axons formed functional glutamatergic synapses onto adult-born [NG2.sup.+] oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult...
- 7From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedThe integrity of peripheral nerves relies on communication between axons and Schwann cells. The axonal signals that ensure myelin maintenance are distinct from those that direct myelination and are largely unknown. Here...
- 8From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedWe developed a technique for performing whole-cell patch-clamp recordings from genetically identified neurons in behaving Drosophila. We focused on the properties of visual interneurons during tethered flight, but this...
- 9From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedComputational modeling of the nervous system serves two important purposes: to assess our understanding of neural systems and to generate predictions that will lead to new experiments and eventual improvements of the...
- 10From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedActivation of cannabinoid type-1 receptors ([CB.sub.1]) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined...
- 11From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-Reviewed
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
Extracellular factors may act on cells in two distinct modes: an acute increase in concentration as a result of regulated secretion, or a gradual increase in concentration when secreted constitutively or from a distant... - 12From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedThe authors use in vivo two-photon calcium imaging to examine the responses and network dynamics of layer 2/3 neurons in the primary auditory cortex of mice in response to pure tones. They find that local populations in...
- 13From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedSo you want to be a scientist? by Philip A Schwartzkroin Oxford University Press, 2009 208 pages, paperback, $19.95 ISBN 0195333543 The decision to enter into a career in research is often made rather...
- 14From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedSynaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity. We examined the role of the schizophrenia risk factor DISC1 in the maintenance of spine morphology and function. We found that...
- 15From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedTo assess the importance of brain cytochrome P450 (P450) activity in [mu] opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated...
- 16From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedElectrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of...
- 17From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedMarch 8th marks International Women's Day. Data from the US Bureau of Labor Statistics suggests that there is much to celebrate: in the US, women made up about 47% of the overall workforce and 51% of the workforce in...
- 18From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedInvestigating the organization of tone representation in the rodent auditory cortex at high resolution, two new studies in this issue find that the arrangement of relative frequency responsiveness is not preserved at a...
- 19From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedCortical processing of auditory stimuli involves large populations of neurons with distinct individual response profiles. However, the functional organization and dynamics of local populations in the auditory cortex...
- 20From: Nature Neuroscience. (Vol. 13, Issue 3) Peer-ReviewedThe morphology of neurons creates an anatomical challenge for gene expression; proteins are destined for dendritic and axonal terminals that can be located as much as a meter away from the nucleus. For many years the...