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- 1From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedThe ability of viruses to selectively target, replicate within, and destroy tumour cells without deleterious effects in normal cells (oncolysis), makes the use of viruses as an attractive tool for cancer treatment....
- 2From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedEfficient vaccination against viral agents requires a strong T-cell-mediated immune response to clear viral-infected cells. Optimal vaccination can be achieved by administration of recombinant viral vectors encoding...
- 3From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedAccumulation of insoluble aggregates of amyloid-[beta] peptide (A[beta]), a cleavage product of amyloid precursor protein (APP), is thought to be central to the pathogenesis of Alzheimer's disease (AD). Consequently,...
- 4From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedVascularized organ allografts are rapidly destroyed by host immune cells that are recruited along chemokine gradients. Among chemokines, Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) CC...
- 5From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedThe aim of this study was to determine the effect of RNA interference inhibition of mineralocorticoid receptor (MR) on cold-induced hypertension (CIH) and renal damage. Recombinant adeno-associated virus (AAV) carrying...
- 6From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedDespite recent advances in the chemotherapy of chronic hepatitis B (CHB), an effective viral suppression after cessation of therapy has not yet been achieved. To investigate whether hepatitis B virus (HBV)-specific...
- 7From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedOur first review on progress and prospects in cystic fibrosis (CF) gene therapy was published in this series in October 2002. We now summarize the progress made since then and comment on the prospects for CF gene...
- 8From: Gene Therapy. (Vol. 13, Issue 14) Peer-ReviewedWe previously demonstrated that systemic administration of adenovirus serotype 35 (Ad35) vectors to mice does not mediate efficient transduction in organs, probably because expression of the mouse analog of the subgroup...