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- 1From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedChromosome segregation requires the formation of K-fibres, microtubule bundles that attach sister kinetochores to spindle poles. Most K-fibre microtubules originate around the chromosomes through a non-centrosomal...
- 2From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedHow the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal...
- 3From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedIn the version of this article initially published online and in print, Figs 2b and 4a contained panels that did not match those in Supplementary Fig. S5, which showed full uncropped scans corresponding to the specific...
- 4From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedKinases and phosphatases regulate messenger RNA synthesis through post-translational modification of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (ref. 1). In yeast, the phosphatase...
- 5From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedIn mammals, epidermal stem cells located in the bulge region of the hair follicle undergo cycles of activation and dormancy to ensure hair renewal. However, not all these stem cells respond to activation at the same...
- 6From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedIntracellular transport is vital for the function, survival and architecture of every eukaryotic cell. Long-range transport in animal cells is thought to depend exclusively on microtubule tracks. This study reveals an...
- 7From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedFour years into my PhD in the laboratory of Luigi Gorini, a world-renowned bacterial geneticist in the Department of Bacteriology at Harvard Medical School, I concluded that my data did not support the hypothesis of my...
- 8From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedZEB1 is a protein of 1124 amino acids with a predicted relative molecular mass ~124K. However, in Supplementary Fig. S5 (corresponding to Fig. 4a) of our manuscript, the uncropped image of the ZEB1 immunoblot shows two...
- 9From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedCell polarity is an essential feature of nearly all cell types and a prerequisite for fundamental biological processes such as cell morphogenesis, division and migration. In most eukaryotes the small Rho-family GTPase...
- 10From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedCardiomyocyte proliferation is crucial for embryonic heart development, yet the signalling pathways that regulate proliferation are incompletely defined. Olson and colleagues now reveal a central role for the Hippo...
- 11From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedCaspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1). However, the dominant function of caspase 8 is to transmit a pro-survival...
- 12From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedIn the version of this article initially published online and in print, the first sentence in the Acknowledgements section was incorrect. The correct sentence is: We thank E. Baehrecke for critical reading of the...
- 13From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedWallerian degeneration is observed in many neurological disorders, and it is therefore important to elucidate the axonal degeneration mechanism to prevent, and further develop treatment for, such diseases. The...
- 14From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedThe mitotic spindle, a dynamic ensemble of microtubules, microtubule-associated proteins and motor proteins, aligns sister chromatids in the middle of the cell before segregating them to opposite poles (1). Mitotic...
- 15From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedCell elongation and polarization are basic morphogenetic responses to extracellular matrix adhesion. We demonstrate here that human cultured fibroblasts readily polarize when plated on rigid, but not on compliant,...
- 16From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedI have worked at the National Centre for Biological Sciences (NCBS) in Bangalore since 1995, following graduate and postdoctoral training in the biological sciences at Rockefeller University and Columbia University in...
- 17From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedTo establish and maintain their internal organization, living cells must move molecules to their correct locations. Long-range intracellular movements are often driven by motor molecules moving along microtubules,...
- 18From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedPolarity is key to the function of eukaryotic cells. On the establishment of a polarity axis, cells can vectorially target secretion, generating an asymmetric distribution of plasma membrane proteins. From Saccharomyces...
- 19From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedIn most eukaryotes, sperm mitochondria are not inherited, despite entering the ooplasm after fertilization. Miyuki and Ken Sato now show that inCaenorhabditis elegans the disappearance of paternal mitochondria can be...
- 20From: Nature Cell Biology. (Vol. 13, Issue 12) Peer-ReviewedMYC proto-oncogene is a key player in cell homeostasis that is commonly deregulated in human carcinogenesis (1). MYC can either activate or repress target genes by forming a complex with MAX (ref. 2). MYC also exerts...