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- 1From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedStroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a new connection after...
- 2From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedFast axonal conduction depends on myelin, which is formed by Schwann cells in the PNS. We found that the transcription factor Yin Yang 1 (YY1) is crucial for peripheral myelination. Conditional ablation of Yyl in the...
- 3From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedThe 'blue spot', or locus coeruleus (in Latin), visible in fresh tissue of the dorsal pontine brainstem was first described in the eighteenth century by Felix Vicq-d'Azyr. It is the principal brain site for the...
- 4From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedMesencephalic-diencephalic dopaminergic neurons control locomotor activity and emotion and are affected in neurodegenerative and psychiatric diseases. The homeoprotein Otx2 is restricted to ventral tegmental area (VTA)...
- 5From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedConnectomes are generating interest and excitement, both among neuroscientists and the public. This September, the first grants under the Human Connectome Project, totaling $40 million over 5 years, were awarded by the...
- 6From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedAMPA receptors mediate most of the fast postsynaptic response at glutamatergic synapses. The abundance of AMPA receptors in neurons and at postsynaptic membranes is tightly regulated. It has been suggested that changes...
- 7From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedAlthough it has long been posited that sensory adaptation serves to enhance information flow in sensory pathways, the neural basis remains elusive. Simultaneous single-unit recordings in the thalamus and cortex in...
- 8From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedVisual area V4 in the macaque monkey is a cortical area that is strongly involved in color and shape perception. However, fundamental questions about V4 are still debated. V4 was initially characterized as a...
- 9From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedRadial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated...
- 10From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedThere is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a...
- 11From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedThe image on the retina is never stationary. Microscopic relocations of gaze, known as microsaccades, occur even during steady fixation. It has long been thought that microsaccades enable exploration of small regions in...
- 12From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedSynaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this...
- 13From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedA driver's nightmare, prowling a crowded parking garage looking for a space and late for an important appointment. Finally, you find a spot, but the parked cars on either side are so close to the dividing lines that...
- 14From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedToll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for...
- 15From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedAlthough axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord...
- 16From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedMice lacking 5-HT 2C receptors (5-[HT.sub.2C]Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-[HT.sub.2C]Rs only in pro-opiomelanocortin (POMC) neurons. 5-[HT.sub.2C]R deficiency...
- 17From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedSynaptic modifications in the nucleus accumbens (NAc) are important for adaptive and pathological reward-dependent learning. Medium spiny neurons (MSNs), the major cell type in the NAc, participate in two parallel...
- 18From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedAnandamide is best known as one of the endogenous cannabinoid receptor agonists in the brain (1), binding to the same receptors that THC, the active ingredient in marijuana, binds to. In addition to binding to...
- 19From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedNeural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce...
- 20From: Nature Neuroscience. (Vol. 13, Issue 12) Peer-ReviewedThe transient receptor potential TRPV1 is a nonselective cation channel that mediates pain sensations and is commonly activated by a wide variety of exogenous and endogenous, physical and chemical stimuli. Although...