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- 1From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedLife experiences affect behavior, in part via epigenetic modifications that alter DNA transcription. These epigenetic changes can include chromatin or DNA modifications and can silence genes or boost their...
- 2From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedThe zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus...
- 3From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedMany mutations confer one or more toxic function(s) on copper/zinc superoxide dismutase 1 (S0D1) that impair motor neuron viability and cause familial amyotrophic lateral sclerosis (FALS). Using a conformation-specific...
- 4From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedTales of blind individuals having enhanced remaining abilities, often relating to poetry or music, as in the case of the Greek poet Homer, or even crime fighting, in the case of the superhero Daredevil, have long been...
- 5From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedThe development and function of neurons require the regulated expression of large numbers of very specific gene sets. Epigenetic modifications of both DNA and histone proteins are now emerging as fundamental mechanisms...
- 6From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedThe regulation of glycine receptor (GlyR) number at synapses is necessary for the efficacy of inhibition and the control of neuronal excitability in the spinal cord. GlyR accumulation at synapses depends on the...
- 7From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedWhen the brain is deprived of input from one sensory modality, it often compensates with supranormal performance in one or more of the intact sensory systems. In the absence of acoustic input, it has been proposed that...
- 8From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedSensory inputs frequently converge on the brain in a spatially organized manner, often with overlapping inputs to multiple target neurons. Whether the responses of target neurons with common inputs become decorrelated...
- 9From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedInteractions between neurons and glia are a key feature during the assembly of the nervous system. During development, glial cells often follow extending axons, implying that axonal outgrowth and glial migration are...
- 10From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedNeural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely...
- 11From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedCircadian clocks control a variety of neuronal, behavioral and physiological responses, via transcriptional regulation of an appreciable portion of the genome. We describe the complex communication network between the...
- 12From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedNeural stem cells can either self-renew, or differentiate into neurons, astrocytes and oligodendrocytes. How and why this decision is made is unclear. Hoeck et al. now show on page 1365 that Fbw7, a component of the SCF...
- 13From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedTo better understand hereditary spastic paraplegia (HSP), we characterized the function of atlastin, a protein that is frequently involved in juvenile forms of HSP, by analyzing loss- and gain-of- function phenotypes in...
- 14From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedSpeech perception requires the rapid and effortless extraction of meaningful phonetic information from a highly variable acoustic signal. A powerful example of this phenomenon is categorical speech perception, in which...
- 15From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedCategorical perception relates to the way that a continuous sequence of equal physical changes in a stimulus is instead perceived and grouped as two different categories of stimuli (1). In speech, we can create a range...
- 16From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedPresynaptic terminals favor intermediate-conductance [Ca.sub.V]2.2 (N type) over high-conductance [Ca.sub.V]1 (L type) channels for single-channel, [Ca.sup.2+] nanodomain-triggered synaptic vesicle fusion. However, the...
- 17From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedMemory formation and storage require long-lasting changes in memory-related neuronal circuits. Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage. These...
- 18From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedDNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and...
- 19From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedThe field of epigenetics provides neurobiologists with candidate mechanisms for experience-dependent changes in gene transcription. The ability to realize the potential of epigenetics in defining the causal pathways...
- 20From: Nature Neuroscience. (Vol. 13, Issue 11) Peer-ReviewedThe primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the...