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- 1From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedPetruk et al. studied how the histone marks H3K4me3 and H3K27me3 are inherited to daughter chromosomes during DNA replication in Drosophila melanogaster embryos. Using various methods to track protein dynamics following...
- 2From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedNucleosome positioning is influenced by DNA sequence preferences and by various protein complexes, but the relative contribution of these influences has been under debate. This paper describes a functional evolutionary...
- 3From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedThe use of genome sequencing to research disease outbreaks retrospectively has been demonstrated by high-profile cases, such as the recent cholera outbreak in Haiti. But can whole-genome sequencing be used to provide...
- 4From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedRNA POLYMERASE IV (Pol IV) and Pol V are multi-subunit polymerases that are unique to plants and that evolved from Pol II; they mediate RNA-directed DNA methylation at CG, CHG or CHH (where H is any base other than G)...
- 5From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedRaiber et al. mapped the genome-wide distribution of the DNA demethylation intermediate 5-formylcytosine (5fC) in mouse embryonic stem cells by developing a method to covalently tag and purify 5fC-containing DNA...
- 6From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedGroundbreaking technical advances have opened the door for whole-genome analysis in prenatal genetic diagnosis (PND) (1), and recently the proof-of-principle has been provided that non-invasive reconstruction of the...
- 7From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedThe authors outline the focus of the encyclopaedia of mouse DNA elements (Mouse ENCODE), which is already underway. The project will functionally annotate the mouse genome using the same experimental pipelines that were...
- 8From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedAs the list of genetic variants that are implicated in disease gets longer, the challenge is to understand how they contribute to disease phenotypes. A recent study describes a high-throughput yeast system for detecting...
- 9From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedStudies using high-resolution genome-wide approaches have recently reported that genomic and epigenomic alterations frequently accumulate in human pluripotent cells. Detailed characterization of these changes is crucial...
- 10From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedNature Reviews Genetics 12, 179-192 (2011) In Figure 3 of this article, the red box surrounding the second, third and fourth eyes in the third column was incorrectly positioned. The box should surround the third,...
- 11From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedRecent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate...
- 12From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedPre-implantation genetic screening (PGS) is an adjunct technology to in vitro fertilization (IVF) that involves carrying out biopsies and testing embryos of subfertile couples to improve the chances of a successful...
- 13From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedThere has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone...
- 14From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedIt is now possible to make direct measurements of the mutation rate in modern humans using next-generation sequencing. These measurements reveal a value that is approximately half of that previously derived from fossil...
- 15From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedIn the development of gene-based therapies, delivery of ssRNAs is simpler than it is for dsRNAs (as this requires lipid formulation, for example). However, ssRNAs have previously been found to be far less potent for...
- 16From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedIn this study, the evolutionary forces acting on four wild populations of the house mouse Mus musculus were analysed by high-density SNP-genotyping arrays. Statistical analysis showed evidence for selective sweeps at...
- 17From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedImai et al. have identified a role for Pinhead gene transcription in specifying ventral fate in the sea squirt Ciona intestinalis. Furthermore, the genomic position of Pinhead--that is, adjacent to the bone morphogenic...
- 18From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedDNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range of biological processes and diseases. The technology is now available for studying DNA methylation genome-wide, at a high...
- 19From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedKnowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in...
- 20From: Nature Reviews Genetics. (Vol. 13, Issue 10) Peer-ReviewedKnowing the human de novo mutation rate is important for understanding our evolution and the origins of genetic diseases. These two papers characterize the de novo mutation rate, both using Icelandic families. Kong et...