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- 1From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Malignant cells in tumours of B-cell origin account for 0.1% to 98% of the total cell content, depending on disease entity. Recently, gene expression profiles (GEPs) of B-cell lymphomas based on microarray...
- 2From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground To balance the demand for uptake of essential elements with their potential toxicity living cells have complex regulatory mechanisms. Here, we describe a genome-wide screen to identify genes that impact the...
- 3From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin...
- 4From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Trypanosoma brucei is the causative agent of human African sleeping sickness and Nagana in cattle. In addition to being an important pathogen T. brucei has developed into a model system in cell biology....
- 5From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground B-cell non-Hodgkin lymphoma represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is one of the most common subtypes. Family and epidemiological studies suggest an...
- 6From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Coral reefs belong to the most ecologically and economically important ecosystems on our planet. Yet, they are under steady decline worldwide due to rising sea surface temperatures, disease, and pollution....
- 7From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Chenxing Liu1,2 , Fuquan Zhang1,2 , Tingting Li4,5 , Ming Lu4 , Lifang Wang1,2 , Weihua Yue1,2 and Dai Zhang1,2,3 Background MicroRNAs (miRNAs) are small non-coding RNA molecules of ~22 nucleotides that...
- 8From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Lik-Sin Lim1,2 , Yea-Ling Tay1,2 , Halimah Alias1 , Kiew-Lian Wan1,2 and Paul H Dear3 Background The phylum Apicomplexa contains a diverse range of parasites including Plasmodium , Cryptosporidium,...
- 9From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Jan M de Boer1 , Theo JA Borm1 , Taco Jesse2 , Bart Brugmans1 , Lian Wiggers-Perebolte2 , Linda de Leeuw2 , Xiaomin Tang1 , Glenn J Bryan3 , Jaap Bakker4 , Herman J van Eck1 and Richard GF Visser1,5...
- 10From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): David A Miller1 , Garret Suen2 , Kendall D Clements3 and Esther R Angert1 Background Endospore formation is an ancient and complex developmental process exclusive to certain bacteria within the...
- 11From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Tyler J Wilson1 , Liming Lai1 , Yuguang Ban1 and Steven X Ge1 Background Previous Gene Co-expression Studies In recent years, we have witnessed a deluge of new results coming from genome-wide...
- 12From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedAuthor(s): Evaristus Chibunna Mbanefo1,6 , Yu Chuanxin2 , Mihoko Kikuchi1 , Mohammed Nasir Shuaibu1 , Daniel Boamah1 , Masashi Kirinoki3 , Naoko Hayashi3 , Yuichi Chigusa3 , Yoshio Osada4 , Shinjiro Hamano5 and Kenji...
- 13From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground The potato genome sequence derived from the Solanum tuberosum Group Phureja clone DM1-3 516 R44 provides unparalleled insight into the genome composition and organisation of this important crop. A key...
- 14From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedBackground With the advent of next-generation sequencing (NGS) technologies, researchers are now generating a deluge of data on high dimensional genomic variations, whose analysis is likely to reveal rare variants...
- 15From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedBackground To date, exon capture has largely been restricted to species with fully sequenced genomes, which has precluded its application to lineages that lack high quality genomic resources. We developed a novel...
- 16From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Biological systems respond to changes in both the Earth's magnetic and gravitational fields, but as experiments in space are expensive and infrequent, Earth-based simulation techniques are required. A high...
- 17From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Massively parallel sequencing technology is revolutionizing approaches to genomic and genetic research. Since its advent, the scale and efficiency of Next-Generation Sequencing (NGS) has rapidly improved....
- 18From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Cow milk is a complex bioactive fluid consumed by humans beyond infancy. Even though the chemical and physical properties of cow milk are well characterized, very limited research has been done on...
- 19From: BMC Genomics. (Vol. 13) Peer-ReviewedBackground Bacterial genomes displaying a strong bias between the leading and the lagging strand of DNA replication encode two DNA polymerases III, DnaE and PolC, rather than a single one. Replication is a highly...
- 20From: BMC Genomics. (Vol. 13, Issue 1) Peer-ReviewedBackground Targeted genomic enrichment (TGE) is a widely used method for isolating and enriching specific genomic regions prior to massively parallel sequencing. To make effective use of sequencer output, barcoding...