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- 1From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedBotulinum neurotoxins (BoNTs) are zinc endopeptidases that block release of the neurotransmitter acetylcholine in neuromuscular synapses through cleavage of soluble N-ethylmaleimide-sensitive fusion (NSF) attachment...
- 2From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedCrosstalk between the Notch and wingless-type MMTV integration site (WNT) signaling pathways has been investigated for many developmental processes. However, this negative correlation between Notch and WNT/...
- 3From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedAmyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of...
- 4From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedOur understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including...
- 5From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedThe most common forms of neurocristopathy in the autonomic nervous system are Hirschsprung disease (HSCR), resulting in congenital loss of enteric ganglia, and neuroblastoma (NB), childhood tumors originating from the...
- 6From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedThe myeloid-specific transcription factor, CCAAT/enhancer-binding protein [epsilon](C/EBP[epsilon]) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency...
- 7From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedAberrant regulation of growth signaling is a hallmark of cancer development that often occurs through the constitutive activation of growth factor receptors or their downstream effectors. Using validation-based...
- 8From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedTight regulation of calcium levels is required for many critical biological functions. The [Ca.sup.2+]-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating...
- 9From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedThe chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through multiple mechanisms and might promote or inhibit tumor...
- 10From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedThe growth and survival of tumor cells can depend upon the expression of a single oncogene, and therapeutically targeting this oncogene addiction has already proven to be an effective approach in fighting cancer....
- 11From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedA single encounter with a dialysis patient led to the study of complement and neutrophil aggregation, which in turn spawned our work and the remarkable development of the field of vascular biology. As our understanding...
- 12From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedSurvival outcomes for patients with high-risk neuroblastoma (NB) have significantly improved with anti-disi-aloganglioside GD2 mAb therapy, which promotes NK cell activation through antibody-dependent cell-mediated...
- 13From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedCancer cells exhibit an aberrant metabolism that facilitates more efficient production of biomass and hence tumor growth and progression. However, the genetic cues modulating this metabolic switch remain largely...
- 14From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedNew insights into the mechanisms of venous thrombosis Nigel Mackman Original citation: J Clin Invest. 2012;122(7):2331-2336. doi:10.1172/JCI60229. Citation for this corrigendum: J Clin Invest. 2012;122(9):3368....
- 15From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedCells of the immune system have evolved various molecular mechanisms to sense their environment and react to alterations of self. NK cells are lymphocytes with effector and regulatory functions, which are remarkably...
- 16From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedMutations in the photoreceptor-specific flippase ABCA4 are associated with Stargardt disease and many other forms of retinal degeneration that currently lack curative therapies. Gene replacement is a logical strategy...
- 17From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedDystroglycan is a transmembrane glycoprotein that links the extracellular basement membrane to cytoplasmic dystrophin. Disruption of the extensive carbohydrate structure normally present on [alpha]-dystroglycan causes...
- 18From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedMetastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient's likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through...
- 19From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedCD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate...
- 20From: Journal of Clinical Investigation. (Vol. 122, Issue 9) Peer-ReviewedDystroglycan is a prominent cell surface protein that mediates attachment to the extracellular matrix. Although broadly expressed, glycosylated dystroglycan is critically important for muscle cell adherence to its...