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- 1From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedZebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of...
- 2From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedUremia is a complex metabolic state marked by derangement of many signaling molecules and metabolic intermediates; of these, the massively increased levels of FGF23 are among the most striking. It has remained unclear...
- 3From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedFilamentous fungi are a common cause of blindness and visual impairment worldwide. Using both murine model systems and in vitro human neutrophils, we found that NADPH oxidase produced by neutrophils was essential to...
- 4From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedEGFR activation is both a key molecular driver of disease progression and the target of a broad class of molecular agents designed to treat advanced cancer. Nevertheless, resistance develops through several mechanisms,...
- 5From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedCoordinated translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and survival. Hepatocellular...
- 6From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedMutations in numerous genes encoding ribosomal proteins (RPs) occur in 50%-70% of individuals with Diamond-Blackfan anemia (DBA), establishing the disease as a ribosomopathy. As described in this issue of JCI, Sankaran,...
- 7From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedTargeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models Cynthia X. Ma, Shirong Cai, Shunqiang Li, Christine E. Ryan, Zhanfang Guo, W. Timothy...
- 8From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedObesity-induced inflammation is a key component of systemic insulin resistance, which is a hallmark of type 2 diabetes. A major driver of this inflammation/insulin resistance syndrome is the accumulation of...
- 9From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedThe accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging...
- 10From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedCardiac conduction system (CCS) disease, which results in disrupted conduction and impaired cardiac rhythm, is common with significant morbidity and mortality. Current treatment options are limited, and rational efforts...
- 11From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedLeigh syndrome (LS) is a subacute necrotizing encephalomyelopathy with gliosis in several brain regions that usually results in infantile death. Loss of murine Ndufs4, which encodes NADH dehydrogenase (ubiquinone)...
- 12From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedIn prostate cancer, the signals that drive cell proliferation change as tumors progress from castration-sensitive (androgen-dominant) to castration-resistant states. While the mechanisms underlying this change remain...
- 13From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedThe immune system's battle against pathogens includes the "respiratory burst," a rapid release of ROS from leukocytes, thought to play a role in destroying the invading species. In this issue of the JCI, Paiva et al....
- 14From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedIdentification of the cellular mechanisms that mediate cancer cell chemosensitivity is important for developing new cancer treatment strategies. Several chemotherapeutic drugs increase levels of the posttranslational...
- 15From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedTregs play a pivotal role in inducing and maintaining donorspecific transplant tolerance. The T cell immunoglobulin and mucin domain-3 protein (TIM-3) is expressed on many fully activated effector T cells. Along with...
- 16From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedAltered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains poorly understood at the molecular level. Insulin is the primary...
- 17From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedCentral serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid vessels underneath the retina cause subretinal...
- 18From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedVenous thrombosis is a leading cause of morbidity and mortality in industrialized countries, especially in the elderly. Many risk factors have been identified for venous thrombosis that alter blood flow, activate the...
- 19From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedLoss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis Julien van Grevenynghe, Rafael A. Cubas, Alessandra Noto, Sandrina DaFonseca, Zhong He, Yoav Peretz, Abdelali...
- 20From: Journal of Clinical Investigation. (Vol. 122, Issue 7) Peer-ReviewedDiamond-Blackfan anemia (DBA) is a hypoplastic anemia characterized by impaired production of red blood cells, with approximately half of all cases attributed to ribosomal protein gene mutations. We performed exome...