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- 1From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedChronic myelogenous leukemia (CML) arises as a result of a chromosomal translocation in a hematopoietic stem or early progenitor cell that leads to the generation of the oncogenic fusion protein BCR/ABL. CML is...
- 2From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedBilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The...
- 3From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedThe evolutionary struggles from which mutants arise have been documented in almost every living system. In this issue of the JCI, Varela and colleagues extend this list of systems to include neural derivatives of human...
- 4From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedHerpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections, it can also cause permanent brain damage and blindness. There is currently no HSV-1 vaccine. An effective vaccine must...
- 5From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedCutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with over 250,000 new cases annually in the US and is second in incidence only to basal cell carcinoma. cSCC typically manifests as a...
- 6From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedSynaptopodin regulates the actin-bundling activity of [alpha]-actinin in an isoform-specific manner Katsuhiko Asanuma, Kwanghee Kim, Jun Oh, Laura Giardino, Sophie Chabanis, Christian Faul, Jochen Reiser, and Peter...
- 7From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedHemolytic uremic syndrome (HUS) is a potentially life-threatening condition. It often occurs after gastro-intestinal infection with E. coli O157:H7, which produces Shiga toxins (Stx) that cause hemolytic anemia,...
- 8From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedIn a substantial number of human cancers, including 8%-12% of ovarian cancers, the PIK3CA gene, which encodes the p110[alpha] subunit of PI3K, is mutated in such a way that PI3K activity is enhanced. Despite the...
- 9From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Its pathogenesis is frequently linked to liver inflammation. Gain-of-function mutations in the gene encoding [beta]-catenin...
- 10From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedBasal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant...
- 11From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedRASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regulator of blood vessel growth in adult mice and humans. In humans, RASA1 mutations cause capillary malformation-arteriovenous...
- 12From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedParoxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress. Previous research has...
- 13From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedDermatologic disease, although seldom life threatening, can be extremely disfiguring and interfere with the quality of life. In addition, as opposed to other organs, just the aging of skin and its adnexal structure the...
- 14From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedHypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which...
- 15From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedThe CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role of this protein in carcinogenesis remains unclear. To shed light on this issue, we...
- 16From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedI recently had the opportunity to visit a very relaxing and beautiful day spa during the middle-of-the-day break from the sessions at a Keystone meeting. I was having a very tranquil and restorative day, when I went in...
- 17From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedSeveral adenosine receptor subtypes on endothelial, epithelial, mesangial, and inflammatory cells have been implicated in ischemic acute kidney injury, a life-threatening condition that frequently complicates the care...
- 18From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedBM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in tissue repair and tumorigenesis. EPCs migrate from BM to tissues via the bloodstream, but specific chemotactic cues...
- 19From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedBrown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence in adult humans and its contribution to human metabolism were thought to be mini-mal or...
- 20From: Journal of Clinical Investigation. (Vol. 122, Issue 2) Peer-ReviewedIn 2007, the Texas state constitution was amended to establish the Cancer Prevention and Research Institute of Texas (CPRIT). The new organization was endowed with $3 billion to invest in cancer research in Texas over...