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- 1From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedGlucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet [beta] cells. GLP-1 also modulates gastric emptying and engages...
- 2From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedOne of the first immune cells to respond to an invading pathogen is the neutrophil. Numbers of these cells are tightly regulated; this means that the release of an enormous number of neutrophils from the bone marrow of...
- 3From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedRecombinant viruses hold promise as vectors for vaccines to prevent infectious diseases with significant global health impacts. One of their major limitations is that preexisting anti-vector neutralizing antibodies can...
- 4From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedAmyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration, which ultimately leads to paralysis and death. Mutation of TAR DNA binding protein 43 (TDP-43) has been linked to the...
- 5From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedDefining the genetic contribution of rare variants to common diseases is a major basic and clinical science challenge that could offer new insights into disease etiology and provide potential for directed gene-and...
- 6From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedThe practice of transplanting organs from executed prisoners in China appears to be widespread. We vigorously condemn this practice and, effective immediately, will not consider manuscripts on human organ...
- 7From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedGlioblastoma multiforme (GBM) is the most common and lethal of all gliomas. The current standard of care includes surgery followed by concomitant radiation and chemotherapy with the DNA alkylating agent temozolomide...
- 8From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedIn hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome (HUS), pathological biophysical interactions among blood cells, endothelial cells, and soluble factors lead to microvascular...
- 9From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedThe hormone glucagon has long been dismissed as a minor contributor to metabolic disease. Here we propose that glucagon excess, rather than insulin deficiency, is the sine qua non of diabetes. We base this on the...
- 10From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedSuppression of immune responses is necessary to limit damage to host tissue during inflammation, but it can be detrimental in specific immune responses, such as sepsis and antitumor immunity. Recently, immature myeloid...
- 11From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedClinical complications of atherosclerosis arise primarily as a result of luminal obstruction due to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque destabilization leading to rupture....
- 12From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedDNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is...
- 13From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedA noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice Pascal Bernatchez, Arpeeta Sharma, Philip M. Bauer, Ethan Marin, and William C. Sessa...
- 14From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedIt is estimated that one-third of the world's population is infected with Mycobacterium tuberculosis. Infection typically remains latent, but it can reactivate to cause clinical disease. The only vaccine, Mycobacterium...
- 15From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedThe innate immune response involves a variety of inflammatory reactions that can result in inflammatory disease and cancer if they are not resolved and instead are allowed to persist. The effective activation and...
- 16From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedThere is no proven reparative treatment for spinal cord injury (SCI), one of the most common causes of disability in young adults. Developing such a treatment will be hard because repair of SCI requires a multifaceted...
- 17From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedIn the CNS, the hypothalamic arcuate nucleus (ARN) energy-balance circuit plays a key role in regulating body weight. Recent studies have shown that neurogenesis occurs in the adult hypothalamus, revealing that the ARN...
- 18From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedOncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have...
- 19From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedSphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun...
- 20From: Journal of Clinical Investigation. (Vol. 122, Issue 1) Peer-ReviewedAntagonists of L-type [Ca.sup.2+] channels (LTCCs) have been used to treat human cardiovascular diseases for decades. However, these inhibitors can have untoward effects in patients with heart failure, and their overall...