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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedRapamycin is an antibiotic inhibiting eukaryotic cell growth and proliferation by acting on target of rapamycin (TOR) kinase. Mammalian TOR (mTOR) is thought to work through 2 independent complexes to regulate cell...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedManzar Ashtari, (1) Laura L. Cyckowski, (1) Justin F. Monroe, (1) Kathleen A. Marshall, (2) Daniel C. Chung, (2), (3) Alberto Auricchio, (4), (5) Francesca Simonelli, (4), (6) Bart P. Leroy, (7) Albert M. Maguire, (2),...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedThe best-characterized function of dopamine is as a neurotransmitter. However, it also exerts effects on peripheral organs, such as the kidney, which itself synthesizes dopamine through the actions of aromatic amino...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedIn medical and/or graduate school, we are taught to seek new knowledge and to question common wisdom. We learn that therapies for disease have evolved over time. Some outmoded approaches, such as bloodletting, purging,...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedMultidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the role of MRP4 in the development and progression...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedChronic inflammation has long been suspected to support tumorigenesis in a variety of cancers. The IKB kinase (IKK)/NF-KB pathway is the critical signal transduction pathway regulating inflammation, and loss-of-function...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedTherapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or prevention of coronary artery disease (CAD). However, the...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedIn addition to its role as an essential neurotransmitter, dopamine serves important physiologic functions in organs such as the kidney. Although the kidney synthesizes dopamine through the actions of aromatic amino acid...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-Reviewed[beta] -Adrenergic receptors ([beta] -ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases [Ca.sup.2+]-induced [Ca.sup.2+] release via phosphorylation of L-type [Ca.sup.2+]...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedTriple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedThrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant activity. However, the molecular...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedThe many challenges associated with lung transplantation provide a strong rationale for the development of cell- and tissue-based therapies for patients with respiratory failure caused by the loss of lung tissue that is...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedMetastasis depends on the ability of tumor cells to establish a relationship with the newly seeded tissue that is conducive to their survival and proliferation. However, the factors that render tissues permissive for...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedChronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedNanoparticle-based materials, such as drug delivery vehicles and diagnostic probes, currently under evaluation in oncology clinical trials are largely not tumor selective. To be clinically successful, the next...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedSince the development of the first vaccine, controversy about their use has existed. At times, concerns have been justified; at others times, comments have reflected unwarranted claims. The facts about the most recent...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedPlasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism have revealed that miR-33, an...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedB cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedNumerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 7) Peer-ReviewedLaminins and their integrin receptors are implicated in epithelial cell differentiation and progenitor cell maintenance. We report here that a previously unrecognized subpopulation of mouse alveolar epithelial cells...