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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedIn chronic viral infections, [CD8.sup.+] T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific [CD8.sup.+] T cells from mice and...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedPulmonary emphysema is a disease characterized by alveolar cellular loss and inflammation. Recently, excessive apoptosis of structural alveolar cells has emerged as a major mechanism in the development of emphysema....
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedThe podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedInsulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single [beta]...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedThe directed differentiation of iPS and ES cells into definitive endoderm (DE) would allow the derivation of otherwise inaccessible progenitors for endodermal tissues. However, a global comparison of the relative...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedA tale of medicine and murder in the scientific revolution Holly Tucker W.W. Norton and Company. New York, New York, USA. 2011. 304 pp. $25.95. ISBN: 978-0-393-07055-2 (hardcover). Holly Tucker, a medical...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedCardiac hypertrophy and failure are accompanied by a reprogramming of gene expression that involves transcription factors and chromatin remodeling enzymes. Little is known about the roles of histone methylation and...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedCD73 is overexpressed in many types of human and mouse cancers and is implicated in the control of tumor progression. However, the specific contribution from tumor or host CD73 expression to tumor growth remains unknown...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedFrom enlightenment to neuroscience Michel Meulders (translated by Laurence Garey) The MIT Press. Cambridge, Massachusetts, USA. 2010. 264 pp. $27.95. ISBN: 978-0-262-01448-9 (hardcover). In Helmholtz: From...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedPreclinical studies with probiotics continue to unravel mechanisms of cytoprotection and suggest that approaches utilizing microbial products as therapeutics in acute and chronic gastrointestinal disorders could be...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedPatients with atopic dermatitis (AD) often suffer from food allergy and develop flares upon skin contact with food allergens. However, it is unclear whether T cells sensitized to allergens in the gut promote this skin...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedCurrent tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M....
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-Reviewed
Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation
Most degenerative diseases begin with a gradual loss of specific cell types before reaching a threshold for symptomatic onset. However, the endogenous regenerative capacities of different tissues are difficult to study,... - 14From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedThe discovery of the genetic basis for circadian rhythms has expanded our knowledge of the temporal organization of behavior and physiology. The observations that the circadian gene network is present in most living...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedChronic rejection, manifested as small airway fibrosis (obliterative bronchiolitis [OB]), is the main obstacle to long-term survival in lung transplantation. Recent studies demonstrate that the airways involved in a...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedThe mutations that cause Leber congenital amaurosis (LCA) lead to photoreceptor cell death at an early age, causing childhood blindness. To unravel the molecular basis of LCA, we analyzed how mutations in LCA5 affect...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedTo fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such,...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedAngiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition,...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedInsulin, growth hormone (GH), and insulin-like growth factor--1 (IGF-1) play key roles in the regulation of [beta] cell growth and function. Although [beta] cells express the GH receptor, the direct effects of GH on...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 6) Peer-ReviewedObesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the...