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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedHuman cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect humans, is best known for its propensity to cause disease in immunocompromised patients, especially transplant recipients, patients with...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedNeovessel formation is a complex process governed by the orchestrated action of multiple factors that regulate EC specification and dynamics within a growing vascular tree. These factors have been widely exploited to...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedA link between autoimmunity and improved antitumor immunity has long been recognized, although the exact mechanistic relationship between these two phenomena remains unclear. In the present study we have found that...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedType 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to [beta] cells and consequent T cell-mediated destruction of...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedUlcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its role in UC is...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedMucosal antibody responses play a major role in mediating homeostasis with the intestinal flora. It has been suggested that imbalance in the [IgA.sup.+] and [IgG.sup.+] intestinal B cell repertoire may be associated...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedFor over three decades, Mina Bissell, a Distinguished Scientist at the Lawrence Berkeley National Laboratory, has investigated how cells interact with their environment. Her research has helped to reshape cell culture...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedShedding of the extracellular domain of cytokine receptors allows the diffusion of soluble receptors into the extracellular space; these then bind and neutralize their cytokine ligands, thus dampening inflammatory...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedTrefoil factor 1 (TFF1) is a tumor suppressor gene that encodes a peptide belonging to the trefoil factor family of protease-resistant peptides. Although TFF1 expression is frequently lost in gastric carcinomas, the...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedThe neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several mood disorders, including anxiety and...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedAnne Maczulak FT Press. Upper Saddle River, New Jersey, USA. 2011. 224 pp. $24.99. ISBN: 978-0-13-701546-7 (hardcover). Allies and Enemies: How the World Depends on Bacteria, by Anne Maczulak, is an impressive...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedThe success of a non-live vaccine requires improved formulation and adjuvant selection to generate robust T cell immunity following immunization. Here, using protein linked to a TLR7/8 agonist (conjugate vaccine), we...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedCerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition has been independently linked to 3 separate genes: Krev1...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedSteroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification of single-gene causes of SRNS has generated some insights into its pathogenesis; however, additional genes and...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedProinflammatory stimuli induce inflammation that may progress to sepsis or chronic inflammatory disease. The cytokine TNF-[alpha]is an important endotoxin-induced inflammatory glycoprotein produced predominantly by...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedHypoxia inducible factor-1 (HIF-1) is the master transcriptional regulator of the cellular response to altered oxygen levels. HIF-1[alpha]protein is elevated in most solid tumors and contributes to poor disease outcome...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedPannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and astrocytes. Panx1 can be opened at the resting membrane potential by extracellular ATP via the P2X7 receptor (P2X7R). Panx1 opening has...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedHuman cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedNonthyroidal illness syndrome (NTIS) is a state of low serum 3,5,3' triiodothyronine [(T.sub.3]) that occurs in chronically ill patients; the degree of reduction in [T.sub.3] is associated with overall prognosis and...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 5) Peer-ReviewedLung cancer is one of the most common and deadly forms of cancer. Cigarette smoking has been identified as one of the major causes of the disease, but lung cancers can also arise in non-smokers, and research suggests...