Showing Results for
- Academic Journals (47)
Search Results
- 47
Academic Journals
- 47
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedLEOPARD syndrome (LS) is an autosomal dominant "RASopathy" that manifests with congenital heart disease. Nearly all cases of LS are caused by catalytically inactivating mutations in the protein tyrosine phosphatase...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedThe role of adherent-invasive E. coli (AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear whether this...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedSIV infection of natural host species such as sooty mangabeys results in high viral replication without clinical signs of simian AIDS. Studying such infections is useful for identifying immunologic parameters that lead...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedDefining the directionality and quality of influenza virus-specific [CD8.sup.+] T cell cross-reactivity in individuals infected with hepatitis C virus Victoria Kasprowicz, Scott M. Ward, Alison Turner, Alexandros...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedGenetic mutation of the P53 gene leading to loss of p53 transcriptional activity is seen in approximately half of all human cancers. This has led to the suggestion that restoring p53 expression might be a promising...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedEpithelial-mesenchymal transition (EMT) is a tightly regulated process that is critical for embryogenesis but is abnormally activated during cancer metastasis and recurrence. Here we show that a switch in CD44...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedThe transcription factor p53 is a tumor suppressor. As such, the P53 gene is frequently altered in human cancers. However, over 80% of the P53 mutations found in human cancers are missense mutations that lead to...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedAllergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic asthma with an...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedFood allergies affect up to 6% of young children and 3%-4% of adults. They encompass a range of disorders that may be IgE and/or non-IgE mediated, including anaphylaxis, pollen food syndrome, food-protein-induced...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedHSCs either self-renew or differentiate to give rise to multipotent cells whose progeny provide blood cell precursors. However, surprisingly little is known about the factors that regulate this choice of self-renewal...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedThe regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing pathway has...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedFluid and [HCO.sub.3.sup.-] secretion are fundamental functions of epithelia and determine bodily fluid volume and ionic composition, among other things. Secretion of ductal fluid and [HCO.sub.3.sup.-]in secretory...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedMalaria caused by Plasmodium falciparum results in approximately 1 million annual deaths worldwide, with young children and pregnant mothers at highest risk. Disease severity might be related to parasite virulence...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedPlasmacytoid DCs (pDCs) are innate immune cells that are specialized to produce IFN-[alpha] and to activate adaptive immune responses. Although IFN-[alpha] inhibits HIV-1 replication in vitro, the production of...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedHuman chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity Amie S. Corbin, Anupriya Agarwal, Marc Loriaux, Jorge Cortes, Michael W. Deininger, and Brian J. Druker...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedKaposi sarcoma herpesvirus (KSHV), a human gammaherpesvirus, is the etiological agent for the endothelial-derived Kaposi sarcoma (KS) and also for certain lymphoproliferative disorders. In these lymphoproliferations,...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedHypertrophie cardiomyopathy (HCM) is a leading cause of sudden death in children and young adults. Abnormalities in several signaling pathways are implicated in the pathogenesis of HCM, but the role of the...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedAcute lung injury (ALI) is a life-threatening condition in critically ill patients. Injury to the alveolar epithelium is a critical event in ALI, and accumulating evidence suggests that it is linked to proapoptotic...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedThe mammalian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryonic development, is implicated in cell cycle regulation and the DNA damage response. Its role in tumor...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 3) Peer-ReviewedIn this issue of the JCI, Wu et al. and Marin et al. describe two new mouse models of inherited disorders of the RAS/MAPK signal transduction pathway that display hypertrophic cardiomyopathy (HCM); the model from the...