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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedThum et al. conclude that microRNA-21 (miR-21) is essential for cardiac hypertrophy and fibrosis in response to pressure overload (1). They also claim that our failure to observe a blockade to these processes in mice...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedThe tumor stroma is critical in cancer progression; understanding its formation is therefore important biologically and therapeutically. In this issue of the JCI, Elkabets et al. report on the generation of data in mice...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedRepair of cartilage injury with hyaline cartilage continues to be a challenging clinical problem. Because of the limited number of chondrocytes in vivo, coupled with in vitro de-differentiation of chondrocytes into...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedRecent studies have focused on understanding the neural mechanisms underlying the emergence of clinical signs and symptoms in early stage Huntington disease (HD). Although cell-based assays have focused on cell...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedParkinson disease (PD) is characterized neuropathologically by the presence of Lewy bodies--intracytoplasmic inclusions that are primarily composed of aggregated [alpha]-synuclein ([alpha]-syn)--in the cell body of...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedType 1 or invariant NKT (iNKT) cell agonists, epitomized by [alpha]-galactosylceramide, protect against cancer largely by IFN-[gamma]-dependent mechanisms. Here we describe what we believe to be a novel...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-Reviewed
Notch singaling regulates murine atrioventricular conduction and the formation of accessory pathways
Ventricular preexcitation, which characterizes Wolff-Parkinson-White syndrome, is caused by the presence of accessory pathways that can rapidly conduct electrical impulses from atria to ventricles, without the intrinsic... - 8From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedThe role of the Notch signaling pathway in tumor development is complex, with Notch1 functioning either as an oncogene or as a tumor suppressor in a context-dependent manner. To further define the role of Notch1 in...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedSvea Closser Vanderbilt University Press. Nashville, Tennessee, USA. 2010. 256 pp. $59.95. ISBN: 978-0-826-51708-1 (hardcover). In Chasing Polio in Pakistan: Why the World's Largest Public Health Initiative May...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedImmunological tolerance is achieved through recessive and dominant mechanisms. In recessive tolerance the fate of self-reactive T cells is controlled in a cell intrinsic manner such that they undergo cell death or...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedLiver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedTh17 cells are a subset of [CD4.sup.+] T cells with an important role in clearing certain bacterial and fungal pathogens. However, they have also been implicated in autoimmune diseases such as multiple sclerosis....
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedSystemic instigation is a process by which endocrine signals sent from certain tumors (instigators) stimulate BM cells (BMCs), which are mobilized into the circulation and subsequently foster the growth of otherwise...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedPoliovirus invades the nervous system, resulting in paralysis and occasionally death. In 1988, a global initiative was launched by the WHO and partners to eradicate the virus by mass immunization. The effort was largely...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedProteins that end with a CAAX sequence are targeted to cellular membranes by a series of posttranslational modifications that include prenylation, proteolysis, and carboxyl methylation. Two prenyltransferases modify...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedTo be of therapeutic use, autologous stem cells derived from patients with inherited genetic disorders require genetic modification via gene repair or insertion. Here, we present proof of principle that, for diseases...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedThrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by systemic microvascular thrombosis caused by adhesion of platelets to ultra-large vWF (ULVWF) multimers. These multimers accumulate...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedHuntington disease (HD) is an autosomal dominant neurodegenerative disease with complete penetrance. Although the understanding of the cellular mechanisms that drive neurodegeneration in HD and account for the...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedBoth mucosal and systemic immune responses are required for preventing or containing HIV transmission and chronic infection. However, currently described vaccination approaches are largely ineffective in inducing both...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 2) Peer-ReviewedVentricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by accessory myocardial pathways that bypass the annulus fibrosus. This condition increases the risk of atrioventricular tachycardia and,...