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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedCutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of non-Hodgkin lymphomas that affect the skin. The pathogenesis of these conditions is poorly understood. For example, the signaling mechanisms...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedIron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as [beta]-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedNeural stem cells (NSCs) persist in defined brain niches, including the subventricular zone (SVZ), through-out adulthood and generate new neurons destined to support specific neurological functions. Whether brain...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedLate this summer, an outbreak of listeriosis sickened more than 130 individuals in 26 states. The infection, caused by the bacteria Listeria monocytogenes, was eventually linked to contaminated cantaloupe, and the...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedErythropoiesis, the production of red blood cells, must be tightly controlled to ensure adequate oxygen delivery to tissues without causing thrombosis or stroke. Control of physiologic and pathologic erythropoiesis is...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedThe pancreas is a complex organ comprised of three critical cell lineages: islet (endocrine), acinar, and ductal. This review will focus upon recent insights and advances in the biology of pancreatic ductal cells. In...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedHuman mutations in or variants of TBX20 are associated with congenital heart disease, cardiomyopathy, and arrhythmias. To investigate whether cardiac disease in patients with these conditions results from an embryonic...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedIncreased endogenous glucose production (EGP) is a hallmark of type 2 diabetes mellitus. While there is evidence for central regulation of EGP by activation of hypothalamic ATP-sensitive potassium ([K.sub.ATP]) channels...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedMany autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinants. Single nucleotide polymorphisms in PTPN2, which encodes T cell protein tyrosine phosphatase (TCPTP), have been...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedInclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD) is a multisystem degenerative disorder caused by mutations in the valosin-containing protein (VCP) gene. How missense mutations...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedOxidative modification of LDL is an early pathological event in the development of atherosclerosis. Oxidation events such as malondialdehyde (MDA) formation may produce specific, immunogenic epitopes. Indeed, antibodies...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedThe hallmark of type 1 diabetes is specific autoimmune destruction of the insulin-producing [beta]cells of the pancreas. Surprisingly, little is known about the mechanisms regulating the sensitivity and resistance of...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedHerpes simplex encephalitis (HSE) is the most common sporadic viral encephalitis of childhood. Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedHereditary sensory and autonomic neuropathy type 1 (HSAN1) causes sensory loss that predominantly affects the lower limbs, often preceded by hyperpathia and spontaneous shooting or lancinating pain. It is caused by...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedThe discovery that certain high-risk strains of human papillomavirus (HR-HPV) cause nearly 100% of invasive cervical cancer has spurred a revolution in cervical cancer prevention by promoting the development of viral...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedThe majority of human pancreatic cancers have activating mutations in the KRAS proto-oncogene. These mutations result in increased activity of the NF-[kappa]B pathway and the subsequent constitutive production of...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedIron overload causes damage to multiple organs; left untreated, it can be fatal. New therapeutic options are much needed because current treatments are arduous and/or have severe side effects. The underlying cause of...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedVaginal bacterial communities are thought to help prevent sexually transmitted infections. Bacterial vaginosis (BV) is a common clinical syndrome in which the protective lactic acid-producing bacteria (mainly species of...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedWhile it has been well established that the fetal liver originates from foregut endoderm, the identity of the mechanisms that maintain liver mass under both basal and injury conditions remains controversial....
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 12) Peer-ReviewedNF-[kappa]B--inducing kinase (NIK) is an essential upstream kinase in noncanonical NF-[kappa]B signaling. NIK-dependent NF-[kappa]B activation downstream of several TNF receptor family members mediates lymphoid organ...