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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-Reviewed
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
Current therapies for non-Hodgkin lymphoma commonly include CD20 mAb to deplete tumor cells. However, the response is not durable in a substantial proportion of patients. Herein, we report our studies in mice testing the... - 2From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedIn January 2012, Laurie Glimcher (Figure 1) will take a new position as the Dean of Weill Cornell Medical College in New York City. A celebrated immunologist who stresses the importance of interdisci-plinary and...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedIschemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedMutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA). SLC26A4 encodes pendrin, an anion-base exchanger expressed in inner ear epithelial cells that secretes...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedWounds that fail to heal in a timely manner, for example, diabetic foot ulcers, pose a health, economic, and social problem worldwide. For decades, conventional wisdom has pointed to growth factors as the main driving...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedDiabetes mellitus is associated with platelet hyperactivity, which leads to increased morbidity and mortality from cardiovascular disease. This is coupled with enhanced levels of thromboxane (TX), an eicosanoid that...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedCD[4.sup.+] T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion during chronic HIV infection is a hallmark of disease progression. However, the relative contribution of CD[4.sup.+] T...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedViruses are all around us, in the water we drink, in the oceans we swim in, and in many unlikely places. Carl Zimmer starts his book of essays, A Planet of Viruses, by taking us deep into the Cave of Crystals in a...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedInsulin resistance, particularly in skeletal muscle, is a major risk factor for the development of type 2 diabetes. Reducing caloric intake by 10%-40% below ad libitum enhances the sensitivity of skeletal muscle to...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedSkeletal muscle insulin resistance is a key component of the etiology of type 2 diabetes. Caloric restriction (CR) enhances the sensitivity of skeletal muscle to insulin. However, the molecular signals within skeletal...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedDuring lung development, parabronchial SMC (PSMC) progenitors in the distal mesenchyme secrete fibro-blast growth factor 10 (Fgf10), which acts on distal epithelial progenitors to promote their proliferation....
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedFetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition characterized by thrombocytopenia in the newborn. If severe, the thrombocytopenia can lead to intracranial hemorrhage. FNAIT arises when maternal...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedChronic obstructive pulmonary disease (COPD) is caused primarily by cigarette smoking, which leads to persistent inflammation in the airways and subsequent destruction of the lung tissue. Given the central role of...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedTregs not only keep immune responses to autoantigens in check, but also restrain those directed toward pathogens and the commensal microbiota. Control of peripheral immune homeostasis by Tregs relies on their capacity...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedCD[8.sup.+] T cells are a key component of the adaptive immune response to viral infection. An inadequate CD[8.sup.+] T cell response is thought to be partly responsible for the persistent chronic infection that arises...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedType 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans....
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedInsulin resistance is a major risk factor for type 2 diabetes mellitus. The protein encoded by the sirtuin 1 (Sirt1) gene, which is a mouse homolog of yeast Sir2, is implicated in the regulation of glucose metabolism...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedDengue virus (DV) reacts with myeloid DAP12-associating lectin-1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with [MDL-1.sup.+] cells triggers systemic inflammatory response syndrome (SIRS) and...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedMutations in human FYVE, RhoGEF, and PH domain-containing 1 (FGD1) cause faciogenital dysplasia (FGDY; also known as Aarskog syndrome), an X-linked disorder that affects multiple skeletal structures. FGD1 encodes a...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 11) Peer-ReviewedPulmonary hypertension is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Several growth factors, including EGF, PDGF, and TGF-[beta]1, are involved in pulmonary vascular...