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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedPneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the...
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedA fundamental goal in cancer research is the identification of the cell types and signaling pathways capable of initiating and sustaining tumor growth, as this has the potential to reveal therapeutic targets. Stem and...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedOculocutaneous albinism (OCA) is a group of genetic disorders characterized by hypopigmentation of the skin, hair, and eyes. Affected individuals experience reduced visual acuity and substantially increased skin cancer...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-Reviewed(And other white lies): My education in medicine and motherhood Michelle Au Grand Central Publishing. New York, New York, USA. 2011. 336 pp. $24.99. ISBN: 978-0-446-53824-4 (hardcover). Reviewed by Halina...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedAn estimated one-third of the world's population is infected with Mycobacterium tuberculosis, although most affected individuals maintain a latent infection. This control is attributed to the formation of granulomas,...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedIn the 18th century, Thomas Bayes developed his eponymous theorem that teaches us that pretest probabilities can be altered by new information, such as when game show host Monty Hall revealed the goat behind one of the...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedThe specialized epithelial cell of the kidney, the podocyte, has a complex actinbased cytoskeleton. Dynamic regulation of this cytoskeleton is required for efficient barrier function of the kidney. Podocytes are a...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedKidney podocytes are highly differentiated epithelial cells that form interdigitating foot processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte injury results in proteinuric kidney...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedMany tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell proper-ties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedMast cell degranulation is important in the pathogenesis of anaphylaxis and allergic disorders. Many animal venoms contain components that can induce mast cell degranulation, and this has been thought to contribute to...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedThe Holy Grail for the majority of physician-scientists is for their work to translate into something beneficial for human health. As the largest hospital in the United States devoted entirely to clinical research, the...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedPancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously generated pancreas epithelium-specific...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedMycobacterium tuberculosis causes widespread, persistent infection, often residing in macrophages that neither sterilize the bacilli nor allow them to cause disease. How macrophages restrict growth of pathogens is one...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedCrohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients. Identification of reliable...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedIn recent years the description of well-defined molecular subtypes of breast cancer, together with the identification of the driving genetic alterations and signaling pathways, has led to the clinical development of a...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedInfection with HIV-1 leads to severe immunodeficiency in most individuals, but little is known about the profound deregulation of B cell physiology, homeostasis, and function that is detectable soon after infection. In...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedIt is well established that allergy development can be prevented by repeated low-dose exposure to contact allergens. Exactly which immune mechanisms are responsible for this so-called low zone tolerance (LZT) is not...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedFocal segmental glomerulosclerosis (FSGS) is a proteinuric kidney disease caused by breakdown of the glomerular filtration barrier in the kidney. Podocytes are a key cellular component of the glomerular filtration...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-ReviewedImmune cells are key regulators of neoplastic progression, which is often mediated through their release of cytokines. Inflammatory cytokines such as IL-6 exert tumor-promoting activities by driving growth and survival...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 10) Peer-Reviewed
A sodium channel knockin mutant ([Na.sub.v] 1.4-R669H) mouse model of hypokalemic periodic paralysis
Hypokalemic periodic paralysis (HypoPP) is an ion channelopathy of skeletal muscle characterized by attacks of muscle weakness associated with low serum [K. sup.+]. HypoPP results from a transient failure of muscle...