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- 1From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedHuman leukemic stem cells, like other cancer stem cells, are hypothesized to be rare, capable of incomplete differentiation, and restricted to a phenotype associated with early hematopoietic progenitors or stem cells....
- 2From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedIntegrins regulate cell-cell and cell-matrix adhesion and thereby play critical roles in tumor progression and metastasis. Although work in preclinical models suggests that [[beta].sub.1] integrins may stimulate...
- 3From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedIn antiphospholipid syndrome (APS), antiphospholipid antibodies (aPL) binding to [beta]2 glycoprotein I ([beta]2GPI) induce endothelial cell-leukocyte adhesion and thrombus formation via unknown mechanisms. Here we show...
- 4From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedVaccines remain one of the most cost-effective public health measures. Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still...
- 5From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedIn March 2010, Judge Robert Sweet of the Southern District of New York issued a ruling against Myriad Genetics, holder of exclusive patents on the breast cancer genes BRCA1 and BRCA2, indicating that genes should not be...
- 6From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedCongenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis. In addition, aneurysm, coarctation, and dissection of the ascending aorta and aortic arch...
- 7From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedThe hallmarks of the rare inherited disorder Fanconi anemia (FA) are progressive bone marrow failure and susceptibility to cancer. The former is the major cause of death for patients with FA, as it usually occurs...
- 8From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedThe number of people with asthma has increased sharply over the past few decades. It has been hypothesized that this is a result of decreased childhood exposure to microorganisms. Indeed, published data indicate that...
- 9From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedDuring the preparation of this manuscript, a number of references in Table 1 were given incorrectly and references 142 through 150 were omitted from the table and the reference list. The correct table and additional...
- 10From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedGranulocytes are pivotal regulators of tissue injury. However, the transcriptional mechanisms that regulate granulopoiesis under inflammatory conditions are poorly understood. Here we show that the transcriptional...
- 11From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedIn the Methods section titled "Fatty acid infusion," the dose of fatty acids delivered centrally was given incorrectly. The correct sentence appears below. The cannula was connected via a polyethylene catheter to a...
- 12From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedDNA damage is a well-known initiator of tumorigenesis. Studies have shown that most cancer cells rely on aerobic glycolysis for their bioenergetics. We sought to identify a molecular link between genomic mutations and...
- 13From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedStudies in humans and rodents indicate that a minimum amount of stored energy is required for normal pubertal development. The adipocyte-derived hormone leptin is a key metabolic signal to the neuroendocrine...
- 14From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedDysregulated Hedgehog (Hh) signaling has been implicated in a growing number of human cancers. To date, most antagonists of this signaling pathway that have been developed target the Hh receptor Smoothened. However,...
- 15From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedAutoimmune diseases develop in approximately 5% of humans. They can arise when self-tolerance checkpoints of the immune system are bypassed as a consequence of inherited mutations of key genes involved in lymphocyte...
- 16From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedImatinib therapy, which targets the oncogene product BCR-ABL, has transformed chronic myeloid leukemia (CML) from a life-threatening disease into a chronic condition. Most patients, however, harbor residual leukemia...
- 17From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedChronic myeloid leukemia (CML) is a hematopoietic disease characterized by expansion of myeloid blood cells. It is caused by the t(9;22) chromosomal translocation that results in the expression of the fusion tyrosine...
- 18From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedBiofilms are surface-attached agglomerations of microorganisms embedded in an extracellular matrix. Biofilm- associated infections are difficult to eradicate and represent a significant reservoir for disseminating and...
- 19From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedMany patients with advanced bladder cancer develop lethal metastases to the lung. The vasoconstricting protein endothelin-1 (ET-1) has been implicated in this process, although the mechanism(s) by which it promotes...
- 20From: Journal of Clinical Investigation. (Vol. 121, Issue 1) Peer-ReviewedSolute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents. Within the brain, SLC1A1 serves as the...